Interdisciplinary Perspectives on Infectious Diseases

Research Article

Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study

Table 5

Correlation between viral load, absolute monocyte count, inflammatory monocyte, and other laboratory parameters.


Laboratory parameters	HCV viral load		AMC		CD16+ monocyte
Laboratory parameters	R	P value	r	P value	R	P value

Viral load log₁₀ IU/ml	-	-	0.489	0.0002	0.6212	<0.0001

APRI	0.503	0.00015	0.32	0.0207	0.3903	0.00423

AST/ALT ratio	-0.169	0.23229	0.1403	0.3212	0.1042	0.4622

Fib-4 fibrosis score	0.345	0.0122	0.3157	0.023	0.3188	0.0213

Albumin (g/dl)	-0.530	<0.00001	-0.455	0.0007	-0.6114	<0.0001

Total protein (g/dl)	-0.331	0.01641	-0.082	0.5607	-0.1142	0.4203

ALT (IU/L)	0.559	<0.00001	0.325	0.019	0.4154	0.0022

AST (IU/L)	0.580	<0.00001	0.408	0.003	0.5278	<0.00001

Alkaline phosphatase (IU/L)	0.067	0.63583	0.323	0.019	0.1967	0.16216

Fasting glucose (mg/dl)	-0.230	0.10062	-0.093	0.5099	-0.0238	0.8668

Monocyte (10⁹/L)	0.489	0.00024	-	-	0.6755	<0.0001

Monocyte%	0.526	<0.00001	-	-	0.6907	<0.0001

Hb (g/dl)	0.189	0.17936	-0.0758	0.5931	0.0345	0.80803

Platelets count	-0.107	0.45179	0.032	0.8211	0.0607	0.66898

WBC (10⁹/L)	0.086	0.54315	0.5591	<0.00001	0.2233	0.1115

ANC (10⁹/L)	-0.035	0.8074	0.4174	0.0021	0.0929	0.51248

ALC (10⁹/L)	0.078	0.58527	0.233	0.097	0.0592	0.6767

# Eosinophil (10⁹/L)	0.244	0.08177	0.496	0.0002	0.3292	0.01715

NMR	-0.4501	0.00081	-0.540	<0.00001	-0.5664	<0.00001

LMR	-0.456	0.00079	-0.803	<0.0001	-0.6348	<0.00001

Significant; ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; LMR: lymphocyte to monocyte ratio. NMR: neutrophil to monocyte ratio.