Research Article

Role of Chest Computed Tomography versus Real Time Reverse Transcription Polymerase Chain Reaction for Diagnosis of COVID-19: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

AuthorJournalDate (month/year)CountryStudy typeNAgeSexQuality scoreReference

Ai et al.RadiologyFeb/2020ChinaRetrospective cohort101451 ± 15M: 467 (46%)
F: 547 (54%)
10[6]
Fang et al.RadiologyFeb/2020ChinaRetrospective cohort51Median: 45
IQR 39–55
M: 29 (56.9%)
F: 22 (43.1%)
10[20]
Xi et al.RadiologyFeb/2020ChinaRetrospective cohort167NRNR10[21]
Bernheim et al.RadiologyFeb/2020ChinaRetrospective cohort12145.3 ± 16M: 61 (50%)
F: 60 (50%)
12[28]
Wu et al.Clinical Infectious DiseasesFeb/2020ChinaRetrospective cohort80Median: 46.1M: 39 (48.7%)
F: 41 (51.3%)
13[29]
Chung et al.RadiologyFeb/2020ChinaRetrospective cohort2151 ± 14M: 13 (62%)
F: 8 (38%)
11[11]
Shi et al.The Lancet Infectious DiseasesFeb/2020ChinaRetrospective cohort8149.5 ± 11M: 42 (52%)
F: 39 (48%)
11[14]
Yang et al.Journal of InfectionFeb/2020ChinaRetrospective cohort14945.1 ± 13.3M: 81 (54.4%)
F: 68 (45.6%)
12[24]
Guan et al.New England Journal of MedicineFeb/2020ChinaRetrospective cohort1099Median: 47
IQR 35-58
M: 639 (58.1%)
F: 460 (41.9%)
13[31]
Cheng et al.American Journal of RoentgenologyFeb/2020ChinaRetrospective cohort33
11+ve COVID-19
22 Non -COVID
50.36 ± 15.5 for casesM: 8 (72.7%)
F: 3 (27.3%)
10[12]
Huang et al.The Lancet Infectious diseasesFeb/2020ChinaProspective cohort41Median: 40
IQR 41-58
M: 30 (73.2%)
F: 11 (26.8%)
12[13]
Long et al.European Journal of RadiologyMarch/2020ChinaCase control study87
Cases: 36
Control: 51
44.8 ± 18.2 for casesCases: 36
M: 20 (55.6%)
F: 16 (44.4%)
10[22]
Himoto et al.Japanese Journal of RadiologyMarch/2020JapanRetrospective cohort21 (cases: 6, others: 15)Median: 58.5
Range (45–81) for 6 cases
M: 5 (83.3%)
F: 1 (16.7%)
10[18]
Zhang et al.European Respiratory JournalMarch/2020ChinaRetrospective cohort17Median: 48.6
Range (23–74)
M: 8 (47%)
F: 9 (53%)
11[19]
Xu et al.International Journal of Infectious DiseasesMarch/2020ChinaRetrospective cohort51NRM: 25 (49%)
F: 26 (51%)
10[26]
Guan et al.Academic RadiologyMarch/2020ChinaRetrospective cohort5342M: 25 (47.2%)
F: 28 (52.8%)
10[27]
Caruso et al.RadiologyApril/2020ItalyProspective cohort15857 ± 17M: 83 (52.5%)
F: 75 (47.5%)
12[25]
Wang et al.International Journal of Infectious DiseasesApril/2020ChinaRetrospective cohort12541.46 ± 15M: 71 (56.8%)
F: 54 (43.2%)
10[30]
Meng et al.Journal of InfectionApril/2020ChinaRetrospective cohort5842.6 ± 16.5M: 26 (44.8%)
F: 32 (55.2%)
11[17]
Zhifeng et al.Journal of Clinical VirologyApril/2020ChinaRetrospective cohort69Range (23–82)M: 41 (59.4%)
F: 28 (40.6%)
9[32]
Xia et al.Journal of Clinical VirologyApril/2020ChinaRetrospective cohort1056.5 ± 11.16M: 4 (40%)
F:6 (60%)
10[15]
Dai et al.International Journal of Infectious DiseasesApril/2020ChinaRetrospective cohort23444.6 ± 14.8M: 136 (58.1%)
F: 98 (41.9%)
12[33]
Ding et al.European Journal of RadiologyApril/2020ChinaRetrospective cohort11255.8 ± 16.1M: 51 (45.5%)
F: 61 (54.5%)
11[34]
Hu et al.European Journal of RadiologyApril /2020ChinaRetrospective cohort4639.2 ± 9.6 Range (23–60)M: 27 (58.7%)
F: 19 (41.3%)
10[35]
Wang et al.Clinical RadiologyMay/2020ChinaRetrospective cohort114Median: 53
Range (23–78)
M: 56 (49.1%)
F: 58 (50.9%)
11[23]
Li et al.Journal of Clinical VirologyJune/2020ChinaRetrospective cohort22550 ± 14M: 120 (53.3%)
F: 105 (46.7%)
10[16]

N = number of cases; NR = not reported; M = male; F = female.