Role of Chest Computed Tomography versus Real Time Reverse Transcription Polymerase Chain Reaction for Diagnosis of COVID-19: A Systematic Review and Meta-Analysis

Table 3

Performance of chest CT for COVID-19 infection compared to RT-PCR.

Author	TP	TN	FP	FN	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Reference
Ai et al.	580	105	308	21	97% (95–98); RT-PCR 70%	25% (22–30)	65% (62–68)	83% (76–89)	[6]
Fang et al.	50/51	0	0	1/51	98% (90–100)	—	—	—	[20]
Xie et al.	155/167	0	5/167	7/167	95.68% (91–98)	—	—	—	[21]
Long et al.	35/36	0	0	1/36	97.2% (85.4–99.9); RT-PCR 83.3%	—	—	—	[22]
Chung et al.	18/21	0	0	3/21	85.7% (64 to 97)	—	—	—	[11]
Bernheim et al.	94/121	0	0	27/121	77.6% (69 to 85)	—	—	—	[28]
Himoto et al.	6/6	0	15/21	0	100% (54–100)	—	—	—	[18]
Zhang et al.	17/17	0	0	0	100% (80–100)	—	—	—	[19]
Caruso et al.	60	54	42	2	97% (89–99)	56% (45–66)	59% (53–64)	96% (87–99)	[25]
Wang et al.	120/125	0	0	5/125	96% (91–98)	—	—	—	[30]
Wang et al.	110/114	0	0	4/114	96.4% (91–99)	—	—	—	[23]
Shi et al.	81/81	0	0	0	100% (95–100)	—	—	—	[14]
Yang et al.	132/149	0	0	17/149	88.5% (82–93)	—	—	—	[24]
Guan et al.	869/1099	0	0	230/1099	79% (76–81)	—	—	—	[31]
Guan et al.	47/53	0	0	6/53	88.6% (77–96)	—	—	—	[27]
Meng et al.	58/58	0	0	0	100% (94–100)	—	—	—	[17]
Cheng et al.	11/11	0	0	0	100% (71–100)	—	—	—	[12]
Huang et al.	41/41	0	0	0	100% (91–100)	—	—	—	[13]
Zhifeng et al.	NR	NR	NR	NR	12% (4.6–24.3); For PCR 30.16%; (19.2–43)	100% (82–100); For PCR 100%; (54.1–100)	—	—	[32]
Li et al.	225/225	0	0	0	100% (98–100)	—	—	—	[16]
Wu et al.	55/80	0	0	25/80	68.7% (57–78)	—	—	—	[29]
Xu et al.	39/51	0	0	12/51	76.5% (62–87)	—	—	—	[26]
Xia et al.	10/10	0	0	0	100% (69–100)	—	—	—	[15]
Dai et al.	219/234	0	0	15/234	93.6% (89.6–96.3)	—	—	—	[33]
Ding et al.	95/112	0	0	17/112	85% (76.81–90.9)	—	—	—	[34]
Hu et al.	44/46	0	0	2/46	95.6% (85–99.4)	—	—	—	[35]

TP = true positive; TN = true negative; FP = false positive; FN = false negative; PPV = positive predictive value; NPV = negative predictive value, NR = not reported.