Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study

Table 2

Study outcomes: positive PCR tests and COVID-19.

		Bromhexine treatment group	Control group	Overall
n		25	25	50	1.00
Primary outcome (positive PCR test or COVID-19)		2	7	9	0.07
Positive SARS-CoV-2 PCR test, n		2	7	9	0.07
	Asymptomatic	2	2	4	1.00
	Symptomatic	0	5	5	0.02
COVID-19 moderate, n		0	3	3	0.08
COVID-19 severe with hospitalization, n		0	2	2	0.16
Drug nonadherence
	Missed doses of bromhexine, n	4	—	—	—
	Number of missed bromhexine doses, median [IQR]	6 [5.25; 7.5]	—	—	—
Adverse events, n		2	0	2	0.16

n, number of participants; IQR, interquartile range; PCR, polymerase chain reaction.