Measuring the Possibility of Middle Ear Discharge for COVID-19 Test Material

Table 1

Profile of methods for diagnosis of COVID-19.

Methods	Advantage (s)	Disadvantage (s)	Classification according to speed for obtaining the result
Nucleic acid-based	RT-LAMP	Easy and simple to operate and high sensitivity and specificity	More risk of false positive or negative results	1
	RMT	Easy to operate and cost-effective	Sensitivity lower than RT-PCR	2
	RT-PCR	The gold standard for diagnosis of COVID-19 and high sensitivity and specificity	Not only live virus could be detected but also part of the virus	3
	dPCR	Performs better than RT-PCR	High cost	4
	mNGS	The best methods for detection of the pathogen genome	Detected genome is limited and may contain nonspecific genome sequences	5
Serological-based	LFIA	Simple and low cost	Low sensitivity	2
	GICA	Simple and easy to do the test	High false positive	1
	CLIA	High sensitivity and specificity	High false positive	3
	ELISA	High sensitivity and specificity	Possibility of contamination	4
Antigen-based		Simple and quick	Less sensitive than RT-PCR
CT imaging-assisted		Specific finding: ground-glass opacity and consolidation	Not used for determining diagnosis of COVID-19