Effect of Preexisting Asthma on the Risk of ICU Admission, Intubation, and Death from COVID-19: A Systematic Review and Meta-Analysis

Table 1

Brief description of the included studies.

S. no.	Study	Study design	Study country	Sample size	Age groups	Sex (M : F)	Available variables	Result of the study
1	Chhiba et al. [15]	Retrospective cohort	United States of America	1542	<40, 40–70, >70	9 : 10	Mortality	Statistically no association with increased risk of mortality due to COVID-19 in asthmatics
2	Stephanie et al. [16]	Retrospective cohort	United States of America	1298	51	15 : 10	Intubation, mortality	Similar association with intubation and statistically lower risk of mortality in asthma
3	Song et al. [17]	Retrospective cohort	Wuhan, China	961	63 (49,70)	11 : 10	Intubation, mortality	The risk of intubation and mortality were statistically insignificant in asthmatics
4	Mahdavinia et al. [18]	Cohort	United States of America	935	18–65	8 : 10	Intubation, mortality	Statistically, a higher risk of being intubated but a lower risk of mortality in asthma
5	Beurnier et al. [19]	Prospective cohort	France	112	54 (42,67)	3 : 7	ICU admission, intubation, death	No significant association with increased risk of ICU admission, intubation, and mortality in asthma
6	Doriane et al. [20]	Retrospective cohort	Belgium	596	53 ± 18	9 : 10	ICU admission, mortality	Insignificant association between asthma and risk of ICU admission and mortality
7	Calderon et al. [21]	Cross-sectional	Spain	6310	55 ± 20	4 : 10	Mortality	Similar association with mortality
8	Choi et al. [22]	Retrospective cohort	Korea	7590	55.5(41,71)	6 : 10	ICU admission, mortality	Statistically higher association with ICU admission and mortality from COVID-19 in asthma.
9	Bloom et al. [23]	Prospective cohort	United Kingdom	8950	16–49	13 : 10	ICU admission, intubation	No association with increased risk of ICU admission and intubation due to COVID-19 in asthma
10	Robinson et al. [24]	Cohort	United States of America	3248	≥18	3 : 10	Intubation, mortality	Lower association with risk of intubation and mortality in asthma
11	Castilla et al. [25]	Prospective cohort	Spain	35387	<15, 15–65, >65	9 : 10	ICU admission, mortality	Insignificant association with ICU admission and mortality in asthma
12	Almazeedi et al. [26]	Retrospective cohort	Kuwait	1096	41(25–57)	42 : 10	ICU admission, mortality	Significant association with ICU admission and mortality in asthma
13	Mather et al. [27]	Retrospective cohort	United States of America	1045	NR	NR	Intubation, mortality	Insignificant association with increased risk of intubation in asthma
14	Lee et al. [28]	Retrospective cohort	Korea	7272	>20	6 : 10	ICU admission, intubation, mortality	Significantly higher risk of ICU admission, intubation, and mortality in asthma
15	Uribe et al. [29]	Cohort	United States of America	961	66(52,78)	9 : 10	ICU admission, intubation, mortality	Lower rates of ICU admission, intubation, and mortality in asthma. Insignificant statistical association
16	Brinton et al. [30]	Retrospective cohort	United States of America	345	49 ± 6	NR	Intubation, mortality	Equal association with risk of intubation and mortality between asthmatic and nonasthmatic patients
17	Kipourou et al. [31]	Prospective cohort	Kuwait	3995	41 ± 7	24 : 10	ICU admission, mortality	Statistically significant risk of ICU admission and mortality in asthma
18	Schonfeld et al. [32]	Retrospective cohort	Argentina	207079	41(2,55)	9 : 10	ICU admission, mortality	Similar association of risk of ICU admission mortality in asthma
19	Rosenthal et al. [33]	Retrospective cohort	United States of America	727	46.61	NR	ICU admission, intubation, mortality	Higher association with risk of ICU admission, intubation, and mortality in asthma

Age is expressed in median (IQR) or mean (SD) or range. SARS-Cov-2 RT-PCR: severe acute respiratory syndrome coronavirus-2 reverse transcriptase polymerase chain reaction.