Table of Contents
ISRN Hematology
Volume 2011, Article ID 473152, 4 pages
Case Report

Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?

1Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2300RC Leiden, The Netherlands
2Department of Clinical Chemistry, Westeinde Hospital, Lijnbaan 32, 2512 VA, The Hague, The Netherlands

Received 10 March 2011; Accepted 28 April 2011

Academic Editors: H. Knecht, C. Martinez, and F. Oberg

Copyright © 2011 P. C. Giordano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS in favor of HbF, possibly reducing the severity of the disease. We believe that it would be worthwhile to monitor the course of the disease comparing cases with identical genotypes with and without iron depletion, and we advise to consider chelation therapy to reduce iron overload in patients with SCD.