Table of Contents
ISRN Dentistry
Volume 2011 (2011), Article ID 791393, 9 pages
http://dx.doi.org/10.5402/2011/791393
Research Article

Autoantibodies to the 𝜷 𝟏 -Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction

1Pharmacology Unit, School of Dentistry, University of Buenos Aires, 1122AAH Buenos Aires, Argentina
2Argentine National Research Council (CONICET), Buenos Aires, Argentina

Received 23 May 2011; Accepted 6 July 2011

Academic Editors: D. Grenier, M. H. Parkar, and J. Walters

Copyright Β© 2011 Marcela Segovia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The presence of serum autoantibodies in periodontitis (P) patients against 𝛽 1 -adrenoceptor ( 𝛽 1 -AR), using cardiac membranes or a synthetic 𝛽 1 -AR peptide corresponding to the second extracellular loop of human 𝛽 1 -AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti- 𝛽 1 -AR IgG titters correlated with the decrease in HRV of the same patients and the anti- 𝛽 1 -AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the 𝛽 1 -AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti- 𝛽 1 -AR autoantibodies in alteration of myocardial contractility.