Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
Figure 1
Ambulatory activity in ICR mice after single subcutaneous administration of saline or 0.25–2 mg/kg of NIC. The figure shows normalized ambulatory activity that was obtained by normalizing the actual ambulatory measurement using total ambulatory activity during the 30 min adaptation period before administration to each mouse. (a) Time courses of ambulatory activity after subcutaneous administration of saline or 0.25–2 mg/kg of NIC. Symbols represent mean values of ambulatory activity for 10 min periods, and vertical lines indicate standard error of the mean (SEM). = 40–100 animals per dose group. (b) Total ambulatory activity over 60 min after administration of saline or various doses of NIC. Filled columns indicate mean values of total ambulatory activity for 60 min, and vertical lines indicate SEM. Data in Figure 1(a) were analyzed by repeated measures ANOVA, followed by one-way ANOVA and Dunnett’s test. * compared with saline control at each time point. Data in Figure 1(b) were analyzed using one-way ANOVA, followed by Dunnett’s test. * compared with saline control.
