Effect of Chronic L-Dopa or Melatonin Treatments after Dopamine Deafferentation in Rats: Dyskinesia, Motor Performance, and Cytological Analysis
Figure 3
The three groups, 6-OHDA, 6-OHDA + LD, and 6-OHDA + melatonin confer certain susceptibility to dyskinesia during the course of the experiment, but the overall AIM severity is most pronounced in rats with 6-OHDA + LD treatment. (a) Time course of AIM development during the chronic LD and melatonin treatments period. Values give total (locomotive + axial + orolingual + limb AIMs) integrated AIM scores per testing session as group means ± SEM. (b) Time course of total AIM scores/monitoring period after a single treatment of LD or melatonin (treatment day 30).
