Effect of Chronic L-Dopa or Melatonin Treatments after Dopamine Deafferentation in Rats: Dyskinesia, Motor Performance, and Cytological Analysis
Figure 4
Sequences of video recordings from rats affected by locomotive (a), axial (b) orolingual (c), and forelimb AIMs (d). Locomotive AIMs (a) comprise circular movement towards the contralateral side to the lesion. Only locomotive movements involving all four limbs are rated under this AIM category. The sequence in (b) shows a torsion movement of the neck and upper trunk towards the contralateral side to the lesion. Body torsion is maximally severe (>90°), causing the rat to lose equilibrium. Orolingual AIMs (c) include opening and closing of the jaws and tongue protrusion towards the side contralateral to the lesion (arrow). A black circle in (d) highlights purposeless up and down translocation of the Parkinsonian (right) forelimb.
