Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse
Figure 6
Cardiomyocyte Autophagic Vacuolization and release of cTnI. (a) Cardiomyocytes exhibiting large ubiquitinated protein aggregates (arrow) from images as shown in Figure 5 were counted in consecutive fields of 0.2 mm2 from cardiac section of nontreated and doxorubicin-treated 1 month and 3 months WT and KO hearts (WTD, KOD) (). The average values SD were plotted with a significant number of ubiquitin cardiomyocytes in KOD, **. (b) The release of cTnI was determined in whole serum from WT, KO, WTD, and KOD mice (), the average values ± SD were plotted (), **.
