Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 839560, 10 pages
http://dx.doi.org/10.1155/2014/839560
Research Article

Factor VIII-Related Antigen Detects Phenotypic Change of Sinusoidal to Vascular Endothelium in Hepatic Fibrosis of Elderly Cadavers

Department of Medical Education and Center for Anatomy and Functional Morphology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

Received 17 March 2014; Revised 29 May 2014; Accepted 6 July 2014; Published 22 September 2014

Academic Editor: Zvi Ackerman

Copyright © 2014 Ki M. Mak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Wisse, R. B. de Zanger, K. Charels, P. van der Smissen, and R. S. McCuskey, “The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse,” Hepatology, vol. 5, no. 4, pp. 683–692, 1985. View at Publisher · View at Google Scholar · View at Scopus
  2. K. M. Mak and C. S. Lieber, “Alterations in endothelial fenestrations in liver sinusoids of baboons fed alcohol: a scanning electron microscopic study,” Hepatology, vol. 4, no. 3, pp. 386–391, 1984. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Simionescu and M. Simionescu, “The cardiovascular system,” in Cell and Tissue Biology: A Textbook of Histology, L. Weiss, Ed., pp. 355–400, Urban & Schwarzenberg, Baltimore, Md, USA, 6th edition, 1988. View at Google Scholar
  4. A. Martinez-Hernandez and J. Martinez, “The role of capillarization in hepatic failure: studies in carbon tetrachloride-induced cirrhosis,” Hepatology, vol. 14, no. 5, pp. 864–874, 1991. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Smedsrod, P. J. de Bleser, F. Braet et al., “Cell biology of liver endothelial and Kupffer cells,” Gut, vol. 35, no. 11, pp. 1509–1516, 1994. View at Publisher · View at Google Scholar · View at Scopus
  6. D. G. le Couteur, A. Warren, V. C. Cogger et al., “Old age and the hepatic sinusoid,” Anatomical Record, vol. 291, no. 6, pp. 672–683, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Schaffner and H. Popper, “Capillarization of hepatic sinusoids in man,” Gastroenterology, vol. 44, pp. 239–242, 1963. View at Google Scholar · View at Scopus
  8. T. Horn, P. Christofferson, and J. H. Henriksen, “Alcoholic liver injury: defenestration in noncirrhotic livers—a scanning electron microscopic study,” Hepatology, vol. 7, no. 1, pp. 77–82, 1987. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Urashima, M. Tsutsumi, K. Nakase, J.-S. Wang, and A. Takada, “Studies on capillarization of the hepatic sinusoids in alcoholic liver disease,” Alcohol and Alcoholism, vol. 28, pp. 77–84, 1993. View at Google Scholar · View at Scopus
  10. B. Xu, U. Broome, M. Uzunel et al., “Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis,” The American Journal of Pathology, vol. 163, no. 4, pp. 1275–1289, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Bhunchet and K. Fujieda, “Capillarization and venularization of hepatic sinusoids in porcine serum-induced rat liver fibrosis: a mechanism to maintain liver blood flow,” Hepatology, vol. 18, no. 6, pp. 1450–1458, 1993. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Dubuisson, L. Boussarie, C.-A. Bedin, C. Balabaud, and P. Bioulac-Sage, “Transformation of sinusoids into capillaries in a rat model of selenium-induced nodular regenerative hyperplasia: an immunolight and immunoelectron microscopic study,” Hepatology, vol. 21, no. 3, pp. 805–814, 1995. View at Google Scholar · View at Scopus
  13. P. F. Lalor, W. K. Lai, S. M. Curbishley, S. Shetty, and D. H. Adams, “Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo,” World Journal of Gastroenterology, vol. 12, no. 34, pp. 5429–5439, 2006. View at Google Scholar · View at Scopus
  14. E. R. Weibel and G. E. Palade, “New cytoplasmic components in arterial endothelia,” Journal of Cell Biology, vol. 23, pp. 101–112, 1964. View at Publisher · View at Google Scholar · View at Scopus
  15. M. J. Holestelle, H. G. M. Geertzen, I. H. Straatsburg, T. M. van Gulik, and J. A. van Mourik, “Factor VIII expression in liver disease,” Thrombosis and Haemostasis, vol. 91, no. 2, pp. 267–275, 2004. View at Google Scholar · View at Scopus
  16. Y. Fukuda, H. Nagura, M. Imoto, and Y. Koyama, “Immunohistochemical studies on structural changes of the hepatic lobules in chronic liver diseases,” American Journal of Gastroenterology, vol. 81, no. 12, pp. 1149–1155, 1986. View at Google Scholar · View at Scopus
  17. C. Babbs, N. Y. Haboubi, J. M. Mellor, A. Smith, B. P. Rowan, and T. W. Warnes, “Endothelial cell transformation in primary biliary cirrhosis: a morphological and biochemical study,” Hepatology, vol. 11, no. 5, pp. 723–729, 1990. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Gan, S. Chitturi, and G. C. Farrell, “Mechanisms and implications of age-related changes in the liver: nonalcoholic fatty liver disease in the elderly,” Current Gerontology and Geriatrics Research, vol. 2011, Article ID 831536, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Noureddin, K. P. Yates, I. A. Vaughn et al., “Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients,” Hepatology, vol. 58, pp. 1644–1654, 2013. View at Google Scholar
  20. X. Xu, L. K. Hueckstaedt, and J. Ren, “Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy,” Journal of Hepatology, vol. 59, no. 2, pp. 308–317, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. K. M. Mak, A. J. Kwong, E. Chu, and N. M. Hoo, “Hepatic steatosis, fibrosis, and cancer in elderly cadavers,” Anatomical Record, vol. 295, no. 1, pp. 40–50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. K. M. Mak, E. Chu, K. H. V. Lau, and A. J. Kwong, “Liver fibrosis in elderly cadavers: Localization of collagen types I, III and IV, α-smooth muscle actin, and elastic fibers,” Anatomical Record, vol. 295, no. 7, pp. 1159–1167, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. K. M. Mak, L. L. Chen, and T. F. Lee, “Codistribution of collagen type IV and laminin in liver fibrosis of elderly cadavers: immunohistochemical marker of perisinusoidal basement membrane formation,” Anatomical Record, vol. 296, no. 6, pp. 953–964, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Lenzi, G. Alpini, M. H. Liu, J. H. Rand, and N. Tavoloni, “Von Willebrand factor antigen is not an accurate marker of rat and guinea pig liver endothelial cells,” Liver, vol. 10, no. 6, pp. 372–379, 1990. View at Google Scholar · View at Scopus
  25. A. J. McLean, V. C. Cogger, G. C. Chong et al., “Age-related pseudocapillarization of the human liver,” Journal of Pathology, vol. 200, no. 1, pp. 112–117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. V. C. Cogger, A. Warren, R. Fraser, M. Ngu, A. J. McLean, and D. G. Le Couteur, “Hepatic sinusoidal pseudocapillarization with aging in the non-human primate,” Experimental Gerontology, vol. 38, no. 10, pp. 1101–1107, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. S. N. Hilmer, V. C. Cogger, R. Fraser, A. J. McLean, D. Sullivan, and D. G. le Couteur, “Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat,” Hepatology, vol. 42, no. 6, pp. 1349–1354, 2005. View at Publisher · View at Google Scholar · View at Scopus