Table of Contents
Journal of Allergy
Volume 2012, Article ID 817910, 10 pages
Review Article

Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination

1Departments of Otorhinolaryngology, Head and Neck Surgery, and Plastic Surgery, Asklepios Medical School, Lohmuehlenstraß 5, 20099 Hamburg, Germany
2Allergy and Intolerance Laboratory, Medical Clinic III, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstraße 4a, 91054 Erlangen, Germany

Received 28 February 2012; Revised 16 May 2012; Accepted 13 June 2012

Academic Editor: Luis M. Teran

Copyright © 2012 Hendrik Graefe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aspirin-exacerbated respiratory disease (AERD) refers to aspirin sensitivity, chronic rhinosinusitis (CRS), nasal polyposis, asthma, eosinophil inflammation in the upper and lower airways, urticaria, angioedema, and anaphylaxis following the ingestion of NSAIDs. Epidemiologic and pathophysiological links between these diseases are established. The precise pathogenesis remains less defined, even though there is some progress in the understanding of several molecular mechanisms. Nevertheless, these combinations of diseases in patients classified by AERD constitute a fatal combination and may be difficult to treat with standard medical and surgical interventions. This paper reviews in brief the epidemiology, clinical features, diagnosis, molecular pathogenesis, and specific therapies of patients classified by AERD and postulates future attempts to gain new insights into this disease.