Table of Contents
Journal of Allergy
Volume 2014, Article ID 273219, 10 pages
Clinical Study

Treatment of Rhinitis Sicca Anterior with Ectoine Containing Nasal Spray

1Private Health Centre, Institute for ENT Elmshorn, Hermann-Ehlers-Weg 4, 25337 Elmshorn, Germany
2Bitop AG, Stockumer Street 28, 58453 Witten, Germany

Received 28 February 2014; Accepted 17 March 2014; Published 13 April 2014

Academic Editor: Ralph Mösges

Copyright © 2014 Uwe Sonnemann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The safety and efficacy of ectoine nasal spray and ectoine nasal spray with dexpanthenol in the treatment of rhinitis sicca were evaluated in two studies. Design and Methods. Two noninterventional observational studies were performed to evaluate the efficacy and safety of a nasal spray containing ectoine (study 1) and ectoine/dexpanthenol (study 2) over a period of two weeks including comparable numbers of patients suffering from rhinitis sicca anterior. Patients and physicians were asked to rate the efficacy in reducing symptoms and the tolerability over the treatment phase. Results. The treatment in both studies resulted in a clinical and statistical significant reduction of the main diagnosis parameters, nasal airway obstruction, and crust formation. There was also a significant reduction in the secondary diagnosis parameters in both studies. Importantly, the tolerability was very good. During the whole observational study, neither patients nor doctors stopped the medication due to unwanted effects. Conclusion. Rhinitis sicca could be successfully treated with a nasal spray containing ectoine and a nasal spray combining ectoine with dexpanthenol. The combination of both substances led to slight advantages.