Several evidences support the hypothesis that glutamatergic dysfunction may be implicated in the pathogenesis of schizophrenia and in the last few years great interest has been focused on the role of the N-methyl-D-aspartate receptor (NMDAR). Glutamate is the main excitatory neurotransmitter in human CNS and it plays a prominent role in synaptic plasticity, learning, and memory and other cognitive functions. Increasing interest in memantine add-on therapy in schizophrenic patients with negative and cognitive symptoms may suggest that memantine could be a new promising treatment in schizophrenia. The aim of this update was to evaluate clinical data about the memantine effectiveness in schizophrenic patients. Our systematic review of the literature highlights that memantine therapy in schizophrenic patients seems to improve mainly negative symptoms while positive symptoms and cognitive symptoms did not improve significantly.

Giuseppe Di Iorio

Gaia Baroni

Marco Lorusso

Chiara Montemitro

Maria Chiara Spano

Massimo di Giannantonio

Efficacy of Memantine in Schizophrenic Patients: A Systematic Review

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Journal of Amino Acids - Table of contents 2017

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Table of Contents 2017  | Journal of Amino Acids | Hindawi

Journal of Amino Acids

Published Special Issues

Journal of Amino Acids

Table of Contents

Table of Contents: 2017

Efficacy of Memantine in Schizophrenic Patients: A Systematic Review