Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users

Table 1

Areas of significant BOLD signal differences between controls (Controls) and chronic cocaine users (CCUs) while viewing and submitting choices during single-commodity blocks of money now versus money later (MM) and cocaine now versus cocaine later (CC).

Conditions	H	Area	Coordinates				t-value
			MM
View
Money now
Controls (23) > CCUs (24)	n/a
CCUs (24) > Controls (23)	R	Precuneus	6	−52	26	10	3.10
Money later
Controls (24) > CCUs (24)	L	IFG	−54	24	18	12	3.16
	R	Inferior temporal	54	−44	−10	17	3.57
CCUs (24) > Controls (24)	n/a
Submit
Money now
Controls (23) > CCUs (24)	n/a
CCUs (24) > Controls (23)	n/a
Money later
Controls (23) > CCUs (24)	n/a
CCUs (24) > Controls (23)	n/a
CC
View
Cocaine now
Controls (20) > CCUs (23)	n/a
CCUs (23) > Controls (20)	n/a
Cocaine later
Controls (18) > CCUs (23)	n/a
CCUs (23) > Controls (18)	n/a
Submit
Cocaine now
Controls (20) > CCUs (23)	R	Temporal lobe	38	0	−22	10	3.37
	L	Postcentral gyrus	−34	−28	50	11	3.03
CCUs (23) > Controls (20)	n/a
Cocaine later
Controls (18) > CCUs (23)	L	mPFC	6	48	30	10	3.30
CCUs (23) > Controls (18)	n/a

H: hemisphere. Listed areas correspond to location of the maximum voxel of activation with the activity cluster. Coordinates are listed in standard MNI space.