Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users
Table 2
Areas of significant BOLD signal differences between controls (Controls) and chronic cocaine users (CCUs) while viewing and submitting choices during cross-commodity blocks of money now versus cocaine later (MC) and cocaine now versus money later (CM).
Conditions
H
Area
Coordinates
t-value
MC
View
Money now
Controls (25) > CCUs (25)
L
Primary visual
−22
−88
−6
178
7.88
R
Primary visual
30
−84
−6
97
7.01
CCUs (25) > Controls (25)
L
Caudate
−18
0
26
15
3.93
R
Putamen
26
−4
−2
15
3.88
Cocaine later
Controls (10) > CCUs (23)
n/a
CCUs (23) > Controls (10)
n/a
Submit
Money now
Controls (25) > CCUs (25)
n/a
CCUs (25) > Controls (25)
L
Putamen
−30
4
−2
13
3.89
Cocaine later
Controls (10) > CCUs (23)
R
Angular gyrus
50
−60
34
12
3.62
L
Mid. temporal gyrus
−54
−64
10
13
3.53
R
Sup. temporal gyrus
46
−40
14
11
3.43
CCUs (23) > Controls (10)
L
vmPFC
−18
36
−10
11
3.74
CM
View
Cocaine now
Controls (6) > CCUs (21)
n/a
CCUs (21) > Controls (6)
n/a
Money later
Controls (25) > CCUs (23)
n/a
CCUs (23) > Controls (25)
n/a
Submit
Cocaine now
Controls (6) > CCUs (21)
n/a
CCUs (21) > Controls (6)
n/a
Money later
Controls (25) > CCUs (23)
n/a
CCUs (23) > Controls (25)
L
Putamen
−26
4
6
17
3.76
R
Putamen
18
4
6
15
3.24
L
DLPFC
−46
24
18
12
3.28
R
Sup. parietal lobe
34
−72
46
11
3.63
H: hemisphere. Listed areas correspond to location of the maximum voxel of activation with the activity cluster. Sup.: superior. Mid.: middle. DLPFC: dorsolateral prefrontal cortex. Coordinates are listed in standard MNI space.
