Review Article

Is Long-Term Benzodiazepine Use a Risk Factor for Cognitive Decline? Results of a Systematic Review

Table 4

Baseline differences between groups and confounding factors.

StudyBaseline differences between BZD users and nonusersConfounding factors that were adjusted for

Dealberto et al. [18]BZD users were more likely to have depressive symptomsAge, gender, education, depressive symptoms, chronic diseases, psychotropic drugs, race, marital status, housing
Hanlon et al. [19]Unclear: sample characteristics described as a wholeAge, gender, education, depressive symptoms, chronic diseases, alcohol use, smoking, race, insomnia, thyroid medication
Paterniti et al. [20]BZD users were more likely to be older, women, use psychotropic drugs, smoke, have depressive and anxious symptomsAge, gender, education, depressive and anxious symptoms, chronic diseases, alcohol use, smoking, psychotropic drugs
Allard et al. [21]BZD users were olderAge, gender, education, depressive symptoms, chronic diseases, prodromal dementia
Bierman et al. [10]Unclear: sample characteristics described as a wholeAge, gender, education, depressive and anxious symptoms, chronic diseases, alcohol use
van Vliet et al. [22]BZD users were more likely to be women, be institutionalized, have depressive symptoms and less educationGender, education, depressive symptoms
Puustinen et al. [23]BZD users were more likely to be older and womenAge, gender, education, chronic diseases, smoking
Boeuf-Cazou et al. [24]BZD users were more likely to be womenAge, education, chronic diseases, alcohol use, smoking, marital status, cognitive score at baseline, exercise, shiftwork, body mass index
Desplenter et al. [25]BZD users were more likely to be older, women, use psychotropic drugsAge, gender, education, depressive symptoms, use of antipsychotic drugs
Gallacher et al. [26]BZD users were more likely to have anxious symptomsAge, education, anxious symptoms, chronic diseases, alcohol use, smoking, social class, cognitive score at baseline, daytime sleepiness, body mass index
Mura et al. [7]BZD users were more likely to be older, women, have depressive and cardiovascular symptomsGender, education, anxious, depressive and cardiovascular symptoms, chronic diseases, alcohol use, smoking, antidepressant use, insomnia, apolipoprotein E4 genotype, employment, exercise
Gray et al. [27]Heavier BZD users were more likely to be women, have depressive and cardiovascular symptomsAge, gender, education, depressive symptoms, chronic diseases, smoking, exercise, body mass index
Chung et al. [28]Groups were matched on age, gender, ethnicity, education, race, apolipoprotein E4 genotype, marital statusUse of antidepressant drugs
Zhang et al. [29]BZD users were more likely to be white, smoke, use alcohol, have cardiovascular and depressive symptomsAge, gender, education, chronic diseases, alcohol use, smoking, race, family dementia history, brain injury

BZD = benzodiazepine.