When σ is a quasi-definite moment functional with the monic orthogonal polynomial system {Pn(x)}n=0, we consider a point masses perturbation τ of σ given by τ:=σ+λΣl=1mΣk=0ml((1)kulk/k!)δ(k)(xcl), where λ,ulk, and cl are constants with cicj for ij. That is, τ is a generalized Uvarov transform of σ satisfying A(x)τ=A(x)σ, where A(x)=l=1m(xcl)ml+1. We find necessary and sufficient conditions for τ to be quasi-definite. We also discuss various properties of monic orthogonal polynomial system {Rn(x)}n=0 relative to τ including two examples.