Research Article | Open Access

Qi Wang, Jiechang Wen, "Numerical Oscillations Analysis for Nonlinear Delay Differential Equations in Physiological Control Systems", *Journal of Applied Mathematics*, vol. 2012, Article ID 348384, 17 pages, 2012. https://doi.org/10.1155/2012/348384

# Numerical Oscillations Analysis for Nonlinear Delay Differential Equations in Physiological Control Systems

**Academic Editor:**Mehmet Sezer

#### Abstract

This paper deals with the oscillations of numerical solutions for the nonlinear delay differential equations in physiological control systems. The exponential -method is applied to and it is shown that the exponential -method has the same order of convergence as that of the classical -method. Several conditions under which the numerical solutions oscillate are derived. Moreover, it is proven that every nonoscillatory numerical solution tends to positive equilibrium of the continuous system. Finally, the main results are illustrated with numerical examples.

#### 1. Introduction

The nonlinear delay differential equation where has been proposed by Mackey and Glass [1] as model of hematopoiesis (blood cell production). Here, denotes the density of mature cells in blood circulation, is the time delay between the production of immature cells in the bone marrow and their maturation for release in the circulating blood stream, and the production is a single-humped function of . Equation (1.1) has been recently studied by many authors. Mackey and Heidn [2] considered the local asymptotic stability of the positive equilibrium by the well-known technique of linearization. Gopalsamy et al. [3] obtained sufficient and also necessary conditions for all positive solutions to oscillate about their positive steady states. They also obtained sufficient conditions for the positive equilibrium to be a global attractor. For more details of (1.1), we refer to Mackey [4, 5], and Su et al. [6].

Our aim in this paper is to investigate the oscillations of numerical solutions for (1.1). The oscillatory and asymptotic behavior of solutions of delay differential equations has been the subject of intensive investigations during the past decades. The strong interest in this study is motivated by the fact that it has many useful applications in some mathematical models, such as ecology, biology, and spread of some infectious diseases in humans. The general theory and basic results for this paper have been thoroughly studied in [7, 8]. In recent years, much research has been focused on the oscillations of numerical solutions for delay differential equations [9–12]. Until now, very few results dealing with the corresponding behavior for nonlinear delay differential equations have been presented in the literature except for [13]. In [13], the authors investigate the oscillations of numerical solutions for the nonlinear delay differential equation of population dynamics. Different from [13], in our paper, we will consider another nonlinear delay differential equation (1.1) in physiological control systems and obtain some new results. We not only investigate some sufficient conditions under which the numerical solutions are oscillatory but also consider the asymptotic behavior of nonoscillatory numerical solutions.

The structure of this paper is as follows. In Section 2, some necessary definitions and results for oscillations of the analytic solutions are given. In Section 3, we obtain the numerical discrete equation by applying the -methods to the simplified form which comes from making two transformations on (1.1). Moreover, the oscillations of the numerical solutions are discussed, and conditions under which the numerical solutions oscillate are obtained. In Section 4, we investigate the asymptotic behavior of nonoscillatory solutions. In Section 5, we present numerical examples that illustrate the theoretical results for the numerical methods.

#### 2. Preliminaries

Let us state some definitions, lemmas, and theorems that will be used throughout this paper.

*Definition 2.1. *A function of (1.1) is said to oscillate about if has arbitrarily large zeros. Otherwise, is called non-oscillatory. When , we say that oscillates about zero or simply oscillates.

*Definition 2.2. *A sequence is said to oscillate about if is neither eventually positive nor eventually negative. Otherwise, is called non-oscillatory. If is a constant sequence, we simply say that oscillates about . When , we say that oscillates about zero or simply oscillates.

*Definition 2.3. *We say that (1.1) oscillates if all of its solutions are oscillatory.

Theorem 2.4 (see [14]). *Consider the difference equation
**
and assume that and for . Then, the following statements are equivalent:*(1)*every solution of (2.1) oscillates;*(2)*the characteristic equation has no positive roots.*

Theorem 2.5 (see [14]). *Consider the difference equation
**
where , and . Then, the necessary and sufficient conditions for the oscillation of all solutions of (2.2) are and
*

Lemma 2.6. * The inequality holds for and .*

Lemma 2.7. *The inequality holds for and .*

Lemma 2.8 (see [15]). *For all , one has*(1)* if and only if for , for ;*(2)* if and only if for , for ,**where and is a positive constant.*

#### 3. Oscillations of Numerical Solutions

##### 3.1. Two Transformations

In order to study (1.1) conveniently, we will impose two transformations on (1.1) in this subsection.

Together with (1.1), we will consider the initial condition, the initial value problem (1.1), and (3.1) has a unique positive solution for all .

We introduce a similar method in [3]. The change of variables turns (1.1) into the delay differential equation with positive equilibrium , which is denoted as The following theorem gives oscillations of the analytic solution of (3.3).

Theorem 3.1 (see [3]). *Assume that
**
then every positive solution of (3.3) oscillates about its positive equilibrium .*

The following corollary is naturally obtained.

Corollary 3.2. *Assume that all the conditions in Theorem 3.1 hold, then every positive solution of (1.1) oscillates about its positive equilibrium *

Next, we introduce an invariant oscillation transformation , and then (3.3) can be written as where Then, oscillates about if and only if oscillates about zero.

Moreover, since then (3.6) and (3.7) become respectively.

For our convenience, denote then the inequality (3.10) yields

##### 3.2. The Difference Scheme

Let be a given stepsize with integer . The adaptation of the linear -method and the one-leg -method to (3.11) leads to the same numerical process of the following type: where and are approximations to and of (3.11) at , respectively.

Letting and using the expressions of and , we have

*Definition 3.3. *We call the iteration formula (3.15) the exponential -method for (1.1), where and are approximations to and of (1.1) at , respectively.

The following theorem, for the proof of which we refer to [16], allows us to obtain the convergence of exponential -method.

Theorem 3.4. *The exponential -method (3.15) is convergent with order
*

##### 3.3. Oscillation Analysis

It is not difficult to know that oscillates about if and only if is oscillatory. In order to study oscillations of (3.15), we only need to consider the oscillations of (3.14). The following conditions which are taken from [3] will be used in the next analysis: The linearized form of (3.14) is given by Then by (3.12), (3.18) gives It follows from [14] that (3.14) oscillates if (3.19) oscillates under the condition (3.17).

*Definition 3.5. *Equation (3.15) is said to be oscillatory if all of its solutions are oscillatory.

*Definition 3.6. *We say that the exponential -method preserves the oscillations of (1.1) if (1.1) oscillates, then there is a or , such that (3.15) oscillates for . Similarly, we say that the exponential -method preserves the nonoscillations of (1.1) if (1.1) non-oscillates, then there is a or , such that (3.15) nonoscillates for .

In the following, we will study whether the exponential -method inherits the oscillations of (1.1). Equivalently, when Corollary 3.2 holds, we will investigate the conditions under which (3.15) is oscillatory.

Lemma 3.7. *The characteristic equation of (3.18) is given by
*

*Proof. * Letting in (3.18), we have
that is,
which is equivalent to
In view of [17], we know that the stability function of the -method is
By noticing (3.12), thus the characteristic equation of (3.18) is given by (3.20). The proof is completed.

Lemma 3.8. *If condition (3.13) holds, then the characteristic equation (3.20) has no positive roots for .*

*Proof. *Let . By Lemma 2.8, we know that
holds for and . In the following, we will prove that for . Suppose the opposite, that is, there exists a such that , then we get , and
Multiplying both sides of the inequality (3.26) by , we have
Thus, we have the following two cases.*Case 1*. If , then , which contradicts the condition (3.13). *Case 2*. If , then in view of Lemma 2.7, we obtain
that is,
so , which is also a contradiction to (3.13).

In summary, we have, for ,
which implies that the characteristic equation (3.20) has no positive roots. The proof is complete.

Without loss of generality, in the case of , we assume that .

Lemma 3.9. *If condition (3.13) holds and , then the characteristic equation (3.20) has no positive roots for , where
*

*Proof. *Since is an increasing function of when , then, for and ,
In the following, we will prove that the inequality
holds under certain conditions.

The left side of inequality (3.33) can be rewritten as
where
so we only need to prove that for . It is easy to know that is the characteristic equation of the following difference equation
By Theorems 2.4 and 2.5, we know that has no positive roots if and only if
which is equivalent to
We examine two cases depending on the position of : either or . *Case 1*. If , by , (3.38) holds true. *Case 2*. If and
then by Lemma 2.6, we have
Therefore, the inequality (3.33) holds for , where is defined in (3.31). So, we get that the following inequality
holds for and , which implies that the characteristic equation (3.20) has no positive roots. This completes the proof.

*Remark 3.10. *By inequality (3.38) and condition , we have
thus is meaningful.

In view of (3.17), Lemmas 3.8 and 3.9, and Theorem 2.4, we present the first main theorem of this paper.

Theorem 3.11. *If condition (3.13) holds, then (3.15) is oscillatory for
**
where is defined in Lemma 3.9.*

#### 4. Asymptotic Behavior of Nonoscillatory Solutions

In this section, we will study the asymptotic behavior of non-oscillatory solutions of (3.15). We first recall the following result about asymptotic behavior of (3.3).

Lemma 4.1 (see [3]). *Assume that
**
then every solution of the initial value problem is
**
which is non-oscillatory about satisfies
*

From (3.3) and (3.7), we know that the non-oscillatory solution of (3.7) satisfies if Lemma 4.1 is satisfied. Furthermore, is also obtained. In the following, we will prove that the numerical solution of (1.1) can inherit this property.

Lemma 4.2. *Let be a non-oscillatory solution of (3.14), then .*

*Proof. *Without loss of generality, we assume that for sufficiently large . Then by condition (3.17), we have
for sufficiently large . Moreover, it is can be seen from (3.14) that
which gives
thus we have
then the sequence is decreasing, and, therefore,
Next, we prove that . If , then there exist and such that for . Thus, and . So, inequality (4.6) yields
which implies that , where
Thus, as , which is a contradiction to (4.8). This completes the proof.

As a consequence, the second main theorem of this paper is as follows.

Theorem 4.3. *Letting be a positive solution of (3.15), which does not oscillate about , then , where is the positive equilibrium of the continuous system (1.1).*

#### 5. Numerical Examples

In order to verify our results, three numerical examples are examined in this section.

*Example 5.1. *Consider the following equation:
subject to the initial condition
In (5.1), it can be seen that condition (3.6) holds true and . That is, the analytic solutions of (5.1) are oscillatory. In Figures 1–3, we draw the figures of the analytic solutions and the numerical solutions of (5.1), respectively. Set , in Figure 2 and , in Figure 3, respectively. From the two figures, we can see that the numerical solutions of (5.1) oscillate about , which are in agreement with Theorem 3.11.

*Example 5.2. *Let us consider the equation
with the initial value for . In (5.3), it is easy to see that condition (3.6) is fulfilled and . That is, the analytic solutions of (5.3) are oscillatory. In Figures 4–6, we draw the figures of the analytic solutions and the numerical solutions of (5.3), respectively. Set , in Figure 5 and , in Figure 6, respectively. We can see from the three figures that the numerical solutions of (5.3) oscillate about , which are consistent with Theorem 3.11. On the other hand, by direct calculation, we get , so the stepsize is not optimal.

*Example 5.3. *Consider the following equation:
subject to the initial condition
For (5.4), it is easy to see that , so the condition (3.6) is not satisfied. That is, the analytic solutions of (5.4) are non-oscillatory. In Figures 7–9, we draw the figures of the analytic solutions and the numerical solutions of (5.4), respectively. In Figure 7, we can see that as . From Figures 8 and 9, we can also see that the numerical solutions of (5.4) satisfy as . That is, the numerical method inherits the asymptotic behavior of non-oscillatory solutions of (5.4), which coincides with Theorem 4.3.

Furthermore, according to Definition 3.6, we can see from these figures that the exponential -method preserves the oscillations of (5.1) and (5.3) and the non-oscillations of (5.4), respectively.

#### Acknowledgments

Q. Wang’s work was supported by the National Natural Science Foundation of China (no. 11201084). The authors would like to thank Professor Mingzhu Liu, Minghui Song, and Dr. Zhanwen Yang for their useful suggestions.

#### References

- M. C. Mackey and L. Glass, “Oscillation and chaos in physiological control systems,”
*Science*, vol. 197, no. 4300, pp. 287–289, 1977. View at: Publisher Site | Google Scholar - M. C. Mackey and A. D. Heiden, “Dynamical diseases and bifurcations: understanding functional disorders in physiological systems, Funkt,”
*Biology and Medicine*, vol. 1, pp. 156–164, 1982. View at: Google Scholar - K. Gopalsamy, M. R. S. Kulenović, and G. Ladas, “Oscillations and global attractivity in models of hematopoiesis,”
*Journal of Dynamics and Differential Equations*, vol. 2, no. 2, pp. 117–132, 1990. View at: Publisher Site | Google Scholar | Zentralblatt MATH - M. C. Mackey, “Periodic auto-immune hemolytic anemia: an induced dynamical disease,”
*Bulletin of Mathematical Biology*, vol. 41, no. 6, pp. 829–834, 1979. View at: Publisher Site | Google Scholar | Zentralblatt MATH - M. C. Mackey, “Some models in hemopoiesis: predictions and problems,” in
*Biomathematics and Cell Kinetics*, Elsevier, Amsterdam, The Netherlands, 1981. View at: Google Scholar - H. Su, X. Ding, and W. Li, “Numerical bifurcation control of Mackey-Glass system,”
*Applied Mathematical Modelling*, vol. 35, no. 7, pp. 3460–3472, 2011. View at: Publisher Site | Google Scholar | Zentralblatt MATH - K. Gopalsamy,
*Stability and Oscillations in Delay Differential Equations of Population Dynamics*, vol. 74, Kluwer Academic, Dordrecht, The Netherlands, 1992. - D. D. Baĭnov and D. P. Mishev,
*Oscillation Theory for Neutral Differential Equations with Delay*, Adam Hilger, New York, NY, USA, 1991. - M. Z. Liu, J. Gao, and Z. W. Yang, “Oscillation analysis of numerical solution in the $\theta $-methods for equation ${x}^{\text{'}}(t)+ax(t)+{a}_{1}x([t-1])=0$,”
*Applied Mathematics and Computation*, vol. 186, no. 1, pp. 566–578, 2007. View at: Publisher Site | Google Scholar - M. Z. Liu, J. F. Gao, and Z. W. Yang, “Preservation of oscillations of the Runge-Kutta method for equation ${x}^{\text{'}}(t)+ax(t)+{a}_{1}x([t-1])=0$,”
*Computers & Mathematics with Applications*, vol. 58, no. 6, pp. 1113–1125, 2009. View at: Publisher Site | Google Scholar | Zentralblatt MATH - Q. Wang, Q. Zhu, and M. Liu, “Stability and oscillations of numerical solutions for differential equations with piecewise continuous arguments of alternately advanced and retarded type,”
*Journal of Computational and Applied Mathematics*, vol. 235, no. 5, pp. 1542–1552, 2011. View at: Publisher Site | Google Scholar | Zentralblatt MATH - J. F. Gao, “Oscillations analysis of numerical solutions for neutral delay differential equations,”
*International Journal of Computer Mathematics*, vol. 88, no. 12, pp. 2648–2665, 2011. View at: Publisher Site | Google Scholar | Zentralblatt MATH - J. Gao, M. Song, and M. Liu, “Oscillation analysis of numerical solutions for nonlinear delay differential equations of population dynamics,”
*Mathematical Modelling and Analysis*, vol. 16, no. 3, pp. 365–375, 2011. View at: Publisher Site | Google Scholar | Zentralblatt MATH - I. Györi and G. Ladas,
*Oscillation Theory of Delay Differential Equations With Applications*, Academic Press, Oxford, UK, 1991. - M. H. Song, Z. W. Yang, and M. Z. Liu, “Stability of $\theta $-methods for advanced differential equations with piecewise continuous arguments,”
*Computers & Mathematics with Applications*, vol. 49, no. 9-10, pp. 1295–1301, 2005. View at: Publisher Site | Google Scholar - J. Hale,
*Theory of Functional Differential Equations*, Springer, New York, NY, USA, 1977. - Z. Yang, M. Liu, and M. Song, “Stability of Runge-Kutta methods in the numerical solution of equation ${u}^{\text{'}}(t)=au(t)+{a}_{0}u([t])+{a}_{1}u([t-1])$,”
*Applied Mathematics and Computation*, vol. 162, no. 1, pp. 37–50, 2005. View at: Publisher Site | Google Scholar | Zentralblatt MATH

#### Copyright

Copyright © 2012 Qi Wang and Jiechang Wen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.