Mathematical Model and Analysis on the Impacts of Vaccination and Treatment in the Control of the COVID-19 Pandemic with Optimal Control

<div>The effect of <span class="nowrap"><svg height="12.3916pt" id="M282" style="vertical-align:-3.42948pt" version="1.1" viewbox="-0.0498162 -8.96212 19.9989 12.3916" width="19.9989pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M548 455L523 469C505 448 490 439 461 439C416 439 374 447 316 447C144 447 23 310 23 161C23 47 89 -12 179 -12C312 -12 429 106 429 244C429 303 419 344 368 386L371 388C404 383 440 378 474 378C507 378 530 411 548 455ZM350 274C350 191 308 25 198 25C144 25 108 75 108 157C108 264 170 395 276 395C296 395 320 384 333 360C347 334 350 316 350 274Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.347,0)"><path d="M95 130C70 130 46 113 46 88C46 72 54 64 59 64C93 55 121 33 121 -3C121 -41 93 -68 44 -88L55 -117C117 -98 186 -56 186 22C186 91 131 130 95 130Z"></path></g><g transform="matrix(.013,0,0,-0.013,12.49,0)"><path d="M542 242C542 369 469 429 379 468C370 472 372 496 376 513L416 681L400 691L344 648L219 51C167 69 113 128 113 217C113 324 166 387 266 428L252 459C124 418 23 336 23 202C23 95 90 13 205 -8L182 -132C165 -222 191 -254 209 -261L215 -258L270 -7C415 -4 542 98 542 242ZM469 232C469 126 403 33 279 39L355 409C399 394 469 331 469 232Z"></path></g></svg>,</span> and <svg height="10.2124pt" id="M283" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -6.78297 8.63352 10.2124" width="8.63352pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M642 419L635 448C586 435 552 411 532 392C518 379 509 351 496 304C484 260 462 196 445 150C424 93 388 40 314 30L413 508L406 510L344 491L257 36C205 46 175 84 175 169C175 195 180 241 185 277C189 304 190 331 190 358C190 413 175 448 141 448C111 448 69 429 23 373L30 347C51 365 68 375 81 375C93 375 108 368 108 327C108 307 104 268 101 239C98 211 95 180 95 155C95 33 159 -8 248 -14L213 -186C206 -220 221 -254 230 -261L261 -230L306 -11C339 -4 366 6 389 20C431 46 473 87 503 155C533 224 557 286 571 325C586 367 606 393 642 419Z"></path></g></svg> on <svg height="11.927pt" id="M284" style="vertical-align:-3.291101pt" version="1.1" viewbox="-0.0498162 -8.6359 13.1624 11.927" width="13.1624pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M610 18C585 26 567 34 540 68C517 97 499 128 476 171C452 215 425 276 413 304C496 332 570 394 570 494C570 555 545 595 509 619S419 650 364 650H139L133 622C216 615 219 612 203 527L129 132C112 40 105 36 23 28L17 0H279L285 28C199 34 194 40 211 132L239 284H284C320 284 334 275 351 236C374 182 394 140 420 93C459 23 495 -1 592 -8H600L610 18ZM480 485C480 424 449 372 403 342C374 323 338 316 293 316H245L291 562C296 589 301 601 311 608S337 618 358 618C432 618 480 575 480 485Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.086,3.132)"><path d="M245 635C92 635 37 457 37 312C37 149 91 -12 244 -12C395 -12 449 166 449 312C449 469 395 635 245 635ZM243 598C332 598 358 454 358 312C358 173 334 26 245 26C158 26 128 174 128 313S152 598 243 598Z"></path></g></svg> in the presence of <svg height="12.7178pt" id="M285" style="vertical-align:-3.42947pt" version="1.1" viewbox="-0.0498162 -9.28833 10.6561 12.7178" width="10.6561pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.554,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g></svg></div>

Journal of Applied Mathematics

fig8

Figure 8

Figure 8: Mathematical Model and Analysis on the Impacts of Vaccination and Treatment in the Control of the COVID-19 Pandemic with Optimal Control 