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Journal of Automatic Chemistry
Volume 10, Issue 2, Pages 95-100

A computer-controlled potentiometric/spectrophotometric titrator

Merck Sharp & Dohme Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, USA

Copyright © 1988 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A laboratory computer controlled potentiometric titrator interfaced to a diode array spectrophotometer is described. The titrator consists of widely used, commercially available components; therefore, major attention is given to modes of interconnection and software implementation in data format and system control. Replicate potentiometric titrations of glycines gave a relative standard deviation in titre of 1.035% and a relative standard deviation in pH of 0.745%. Replicate spectrophotometric titrations of bromophenol blue were analysed at three wavelengths to yield pKa= 3.898 ± 0.075 (1.9% rsd).

Methods of data presentation and manipulation are presented.