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Journal of Automatic Chemistry
Volume 11, Issue 3, Pages 106-112

Computerized cyclic voltammetric detection after HPLC of the antineoplastic agents etoposide, teniposide, adriamycin and its metabolite adriamycinol in urine samples

1Department of Analytical Pharmacy, State University of Utrecht, Catharijnesingel 60, Utrecht 3511 GH, The Netherlands
2Groot Ziekengasthuis Hospital, Nieuwstraat 34, 's-Hertogenbosch 5211 NL, The Netherlands

Copyright © 1989 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Based on their concentrations in urine, the oxidative cyclic voltammetric mode, using a glassy carbon electrode, permits the determination of etoposide and teniposide, whereas the reductive cyclic voltammetric mode, with a static mercury drop electrode, permits the determination of adriamycin and its metabolite adriamycinol.