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Journal of Automatic Chemistry
Volume 16 (1994), Issue 5, Pages 195-204
http://dx.doi.org/10.1155/S1463924694000246

Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-11C]labelled aldoses

Institute for Biofunctional Research, c/o National Cardiovascular Center, 7-1-5-Chome, Fujishiro-Dai, Suita City, Osaka 565, Japan

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-11C]labelled aldoses, such as [1-11C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synthesis system and control system. The synthesis system has the following functions: supplying reagents; performing reactions; purifying 11C labelled aldose; and preparing an injectable solution of 11C labelled aldose. These operations are performed by the control system in a remote control room. In a preliminary, hot experiment an injectable solution of [1-11C]-D-glucose was obtained. In addition, the operator is exposed to minimal radiation. The radioactivity of [1-11C]-Dglucose was 47 MBq, and the preparation time was 49 min.