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Journal of Automatic Chemistry
Volume 19, Issue 6, Pages 225-233

Application of experimental design to generate relevant information and representative calibration data

1Camo ASA, PO Box 1405, Oslo N-0115, Norway
2Camo ASA, Olav Tryggvasonsgt, Trondheim 24 N-7011, Norway

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The basic requirement for a good calibration is representative data. This paper outlines techniques for selecting samples from an existing population. The concept of factorial designs is explained, and three ways of applying experimental design to generate representative data are described. These are: to vary the experimental conditions; focus on some of the parameters of interest directly (reference values); to vary the underlying conditions which generate consistent variations in the spectra,for example production factors. Finally the paper gives an example of the use of the concept of experimental design to pick out samples from a population.