Journal of Analytical Methods in Chemistry

Journal of Analytical Methods in Chemistry / 1998 / Article

Open Access

Volume 20 |Article ID 140671 |

S. Kitahashi, N. Tatsumi, S. Tagawa, T. Matsui, M. Higashihata, H. Shintaku, S. Tomoda, I. Tsuda, "Diagnosis of infections in newborns using a new particle-mediated immunoassay for serum C-reactive protein", Journal of Analytical Methods in Chemistry, vol. 20, Article ID 140671, 4 pages, 1998.

Diagnosis of infections in newborns using a new particle-mediated immunoassay for serum C-reactive protein


C-reactive protein (CRP) levels were measured using a new particle-mediated immunoassay. Tests for precision and linearity of this method gave satisfactory results. The minimum sensitivity of the assay was 1 ng/ml. Interference by bilirubin (<220mg/l) and haemoglobin (<20g/l) was not observed. Using this method, CRP was assayed as a means of monitoring for infection in newborns up to 72 h after delivery. The pattern of time course elevation curves was similar for both groups (10 healthy subjects and 26 patients), but the serum CRP (ng/ml) of infected newborns rose significantly higher than in healthy subjects at 24 h after birth. The rate of increase of CRP (∆CRP; ng/ml/h) may be a more useful parameter to detect infection, since a significant change in ∆CRP was apparent only 12 h after birth. The reported method was reliable and the parameters obtained were considered clinically useful for early detection of infection.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.