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Journal of Automatic Chemistry
Volume 20, Issue 1, Pages 9-15

Effects of experimental design on calibration curve precision in routine analysis

1Instituto Tecnológico de Pernambuco-ITEP, PE, Brazil
2Departamento de Química Fundamental-CCEN, Universidade Federal de Pernambuco, Brazil
3Departamento de Química-CCEN, Universidade Federal da Paraíba, João Pessoa, PB 58.051-970, Brazil

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A computational program which compares the effciencies of different experimental designs with those of maximum precision (D-optimized designs) is described. The program produces confidence interval plots for a calibration curve and provides information about the number of standard solutions, concentration levels and suitable concentration ranges to achieve an optimum calibration. Some examples of the application of this novel computational program are given, using both simulated and real data.