Journal of Analytical Methods in Chemistry / 2012 / Article / Tab 1 / Research Article
Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study Table 1 Concentration data form validation.
Spiked plasma concentration (pg/ml) Concentration measured (pg/ml) Mean ± Sd
𝑛
=
5
Precision (% CV) Accuracy % 50.00
4
9
.
9
2
±
0
.
4
4
0.80 99.23 100.00
1
0
0
.
2
1
±
1
.
9
1
1.90 98.14 500.00
5
0
2
.
7
3
±
6
.
8
3
1.40 98.65 1000.00
1
0
0
0
.
5
4
±
1
1
.
5
3
1.10 98.92 5000.00
5
0
0
5
.
0
6
±
3
8
.
7
5
0.80 99.28 10000.00
9
9
7
8
.
9
5
±
1
6
0
.
5
6
1.60 98.45 20000.00
1
9
8
7
1
.
0
4
±
3
0
3
.
4
6
1.50 98.53 30000.00
2
9
7
5
9
.
8
2
±
5
0
8
.
4
7
1.70 98.37 40000.00
4
0
3
1
0
.
8
8
±
1
2
3
.
8
5
0.30 99.74 50000.00
5
0
0
8
4
.
8
5
±
2
6
6
.
7
2
0.50 99.55
