Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study

Table 2

Precision and accuracy (analysis with spiked plasma samples at three different concentrations).

Spiked plasma concentration (pg/ml)	Within-run (𝑛=6)			Between-run (𝑛=30)
	Concentration measured (𝑛=6) (pg/ml) (mean ± Sd.)	Precision (%CV)	Accuracy %	Concentration measured (𝑛=30) (pg/ml) (mean ± Sd.)	Precision (%CV)	Accuracy %
150.00	143.40±3.20	2.20	95.60	143.50±3.90	2.70	95.70
15000.00	14746.40±338.40	2.30	98.30	14719.10±248.30	1.70	98.10
35000.00	34935.20±730.40	2.10	99.80	34699.20±498.40	1.40	99.10