Journal of Analytical Methods in Chemistry

Research Article

Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study

Table 4

Mean pharmacokinetic parameters of Memantine in 20 healthy human volunteers after oral administration of 10 mg test and reference products.
Pharmacokinetic details of Memantine in human plasma
Pharmacokinetic ParameterReferenceTest
Mean ± SDMean ± SD
𝐶 m a x (pg/ml) 1 4 3 6 8 . 5 7 ± 4 0 4 4 . 1 6 1 4 3 2 8 ± 4 3 2 4 . 7 6
A U C 0 − 𝑡 (pg·hr/ml) 6 5 4 5 4 5 . 5 ± 7 0 4 2 3 . 1 2 6 7 4 5 6 4 . 4 ± 6 7 8 5 8 . 9 9
A U C 0 − ∞ (pg·hr/ml) 1 0 5 3 4 6 9 . 0 ± 7 7 6 9 0 . 7 9 1 1 3 6 6 0 7 ± 7 4 8 6 2 . 0 4
𝑇 m a x (hr)7.07.5
𝑡 1 / 2 49.2953.35
A U C 0 − ∞ : Area under the curve extrapolated to infinity.
A U C 0 − 𝑡 : Area under the curve up to the last sampling time.
𝐶 m a x : The maximum plasma concentration.
𝑇 m a x : The time to reach peak concentration.