HPLC Method Determination of Isoliquiritin Apioside and Isoliquiritin in Rat Plasma for Application in Pharmacokinetic Study after an Oral Administration of Zhigancao Extract
Figure 2
Typical HPLC chromatograms of the analytes in rat plasma (1, ILA; 2, IL; 3, IS). (a) Chromatogram of blank plasma; (b) chromatogram of plasma sample at LLOQ level (ILA 0.060 μg/mL and IL 0.075 μg/mL); (c) chromatogram of plasma sample at middle QC level (ILA 0.48 μg/mL and IL 0.60 μg/mL); (d) chromatogram of plasma sample obtained from rat (No. 2) at 1 h after an oral administration of Zhigancao extract (ILA 0.78 μg/mL and IL 1.04 μg/mL by calculation).
