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Journal of Analytical Methods in Chemistry
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Journal of Analytical Methods in Chemistry
/
2012
/
Article
/
Tab 2
/
Research Article
HPLC Method Determination of Isoliquiritin Apioside and Isoliquiritin in Rat Plasma for Application in Pharmacokinetic Study after an Oral Administration of Zhigancao Extract
Table 2
Stability of ILA and IL under various conditions in plasma (
).
Analyte
Spiked concentration
(
μ
g/mL)
Stored at room temperature for 12 h
Three freeze-thaw stability
Stored at −20°C for 15 days
Measured
concentration (
μ
g/mL)
RE (%)
Measured
concentration (
μ
g/mL)
RE (%)
Measured
concentration (
μ
g/mL)
RE (%)
ILA
0.12
0.12 ± 0.001
2.7
0.12 ± 0.003
−0.5
0.12 ± 0.002
−0.5
0.48
0.48 ± 0.008
−3.6
0.45 ± 0.018
−5.6
0.48 ± 0.002
0.07
3.07
3.07 ± 0.028
0.03
2.91 ± 0.029
−5.2
2.97 ± 0.006
−3.2
IL
0.15
0.16 ± 0.005
4.3
0.16 ± 0.006
3.9
0.15 ± 0.004
−2.6
0.6
0.59 ± 0.015
−1.1
0.62 ± 0.019
2.7
0.57 ± 0.010
−4.4
3.84
3.82 ± 0.065
−0.4
3.85 ± 0.077
0.19
3.72 ± 0.157
−3.2