High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis

<table>(a) Plasma concentration time course (mg/L) of moxifloxacin in mice (infected ■ or not ▲) after a single i.v. administration of 50 mg per kg of bodyweight (bolus injection) (<svg height="11.0375" id="M17" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
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</svg>); (b) brain concentration time course (<i>μ</i>g/g of brain) of moxifloxacin in mice (infected ■ or not ▲) after a single i.v. administration of 50 mg per kg of body weight (bolus injection) (<svg height="11.0375" id="M18" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">6</tspan>
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Journal of Analytical Methods in Chemistry

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Figure 3

Figure 3: High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis 

Figure 3 | High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis 