Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent

Table 4

Robustness and ruggedness.

Method	ATN taken, μg/mL	Method robustness		Method ruggedness
		Parameters altered
		Volume of; acid, ml^a; RSD, %; (𝑛=3)	Reaction time^b; RSD, %; (𝑛=3)	Interanalysts’; RSD, %; (𝑛=3)	Inter instruments’; RSD, %; (𝑛=3)
A	4.00	1.26	1.46	1.34	2.64
	8.00	0.72	1.72	0.85	3.18
	12.00	0.64	1.28	1.03	3.03
B	8.00	0.85	1.39	1.42	2.86
	16.00	0.52	0.92	1.17	2.47
	24.00	1.18	1.15	1.33	3.26
C	2.00	1.26	1.26	1.06	3.42
	4.00	0.96	1.39	0.88	2.78
	6.00	1.08	0.76	1.24	2.37

^aIn methods A and B, the volume of 5 M HCl was 1.8, 2.0, and 2.2 mL whereas in method C, the volume of 1 M HCl was 4.8, 5.0, and 5.2 mL ^b The reaction time in methods A was 14, 15, and 16 min whereas in methods B and C, the same was 9, 10, and 11 min.