Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent

Table 5

Results of analysis of tablets by the reference and proposed methods.

Tablet Brand name	Label claim mg/tablet	Found (percent of label claim ± SD)^a
		Reference method	Proposed methods
			Method A	Method B	Method C
Atenex-25^b	25	100.3±0.58	100.9±1.06	99.65±0.96	101.0±1.12
			𝑡=1.11	𝑡=1.2	𝑡=1.28
			𝐹=3.34	𝐹=2.74	𝐹=3.33
Atekind-50^c	50	99.67±0.67	101.0±1.09	100.6±1.36	99.81±1.42
			𝑡=2.32	𝑡=1.42	𝑡=0.20
			𝐹=1.48	𝐹=4.12	𝐹=4.49
Aten-100^d	100	100.6±0.82	100.6±1.11	101.1±1.37	99.72±1.69
			𝑡=0.03	𝑡=0.69	𝑡=1.05
			𝐹=1.83	𝐹=2.79	𝐹=4.25

^aMean value of five determinations. ^b,d Marketed by Zydas Healthcare, East Sikkim, India, ^c Marketed by Mankind Pharma Ltd., New Delhi, India, Tabulated t-value at the 95% confidence level is 2.78. Tabulated F-value at the 95% confidence level is 6.39.