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Journal of Analytical Methods in Chemistry
Volume 2013, Article ID 706723, 11 pages
http://dx.doi.org/10.1155/2013/706723
Research Article

Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits

1Department of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China
2Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education/College of Life Science, Northwest University, Xi’an 710069, China
3First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an 710061, China
4Shaanxi Provincial People’s Hospital, Xi’an 710068, China

Received 16 January 2013; Accepted 5 March 2013

Academic Editor: Ying-Yong Zhao

Copyright © 2013 Shixiang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. H. Park, S. K. Lee, and C. H. Kim, “A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats,” Life Sciences, vol. 76, no. 15, pp. 1675–1690, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. K. Lam and T. B. Ng, “A xylanase from roots of sanchi ginseng (Panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase,” Life Sciences, vol. 70, no. 25, pp. 3049–3058, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. G. H. Lu, Q. Zhou, S. Q. Sun, K. S. Y. Leung, H. Zhang, and Z. Z. Zhao, “Differentiation of Asian ginseng, American ginseng and Notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy,” Journal of Molecular Structure, vol. 883-884, no. 1–3, pp. 91–98, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Q. Du, G. Jerz, R. Waibel, and P. Winterhalter, “Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography,” Journal of Chromatography A, vol. 1008, no. 2, pp. 173–180, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Zhao, Y. Q. Liu, and C. R. Yang, “Minor dammarane saponins from Panax notoginseng,” Phytochemistry, vol. 41, no. 5, pp. 1419–1422, 1996. View at Google Scholar · View at Scopus
  6. S. K. Lam and T. B. Ng, “Isolation of a novel thermolabile heterodimeric ribonuclease with antifungal and antiproliferative activities from roots of the sanchi ginseng Panax notoginseng,” Biochemical and Biophysical Research Communications, vol. 285, no. 2, pp. 419–423, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Y. Guan, J. G. Zhou, Z. Zhang et al., “Ginsenoside-Rd from Panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells,” European Journal of Pharmacology, vol. 548, no. 1–3, pp. 129–136, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Shi, Q. Hao, J. Bouissac, Y. Lu, S. Tian, and B. Luu, “Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells,” Life Sciences, vol. 76, no. 9, pp. 983–995, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Wu, W. Zhang, Y. H. Tang et al., “Effect of total saponins of "Panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats,” Phytomedicine, vol. 17, no. 3-4, pp. 233–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. X. D. Peng, L. L. Dai, C. Q. Huang, C. M. He, B. Yang, and L. J. Chen, “Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis,” Biochemical and Biophysical Research Communications, vol. 388, no. 1, pp. 31–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. H. Li, X. L. Li, G. Hong, J. Y. Liu, and M. Y. Zhang, “Determination of panoxadiol and panoxatriol in Panax notoginseng and Yunnan White Powder by supercritical fluid chromatography,” Acta Pharmacologica Sinica, vol. 26, pp. 764–767, 1991. View at Google Scholar
  12. M. Vanhaelen and R. Vanhaelen-Fastre, “Quantitative determination of biologically active constituents in crude extracts of medicinal plants by thin-layer chromatography-densitometry. II. Eleutherococcus senticosus Maxim., Panax ginseng Meyer and Picrorrhiza kurroa Royle,” Journal of Chromatography, vol. 312, pp. 497–503, 1984. View at Google Scholar · View at Scopus
  13. A. D. Lang, T. Y. Zhang, and A. L. Sekhavat, “GC/MS/DS analysis of fatty acid of Panax notoginseng,” Journal of Beijing Normal University, vol. 32, pp. 257–259, 1996. View at Google Scholar
  14. Y. H. Wang, C. Y. Hong, C. F. Chen, and T. H. Tsai, “Determination of triacylglycerols in Panax pseudo-ginseng by HPLC polymeric column,” Journal of Liquid Chromatography and Related Technologies, vol. 19, no. 15, pp. 2497–2503, 1996. View at Google Scholar · View at Scopus
  15. M. Wang, Y. G. Fan, and W. F. Gao, “Quantitative determination of notoginsenoside R1 and ginsenoside Rg1, Rb1 content in total notoginsenosides of Panax notogineseng and Xuesaitong Injection by HPLC gradient elution method,” Chinese Journal of Pharmaceutical Analysis, vol. 20, pp. 410–413, 2000. View at Google Scholar
  16. Y. J. Wei, L. W. Qi, P. Li, H. W. Luo, L. Yi, and L. H. Sheng, “Improved quality control method for Fufang Danshen preparations through simultaneous determination of phenolic acids, saponins and diterpenoid quinones by HPLC coupled with diode array and evaporative light scattering detectors,” Journal of Pharmaceutical and Biomedical Analysis, vol. 45, no. 5, pp. 775–784, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. B. Wan, F. Q. Yang, S. P. Li, Y. T. Wang, and X. M. Cui, “Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD,” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 5, pp. 1596–1601, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. G. C. Kite, E. A. Porter, and M. S. J. Simmonds, “Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry,” Journal of Chromatography A, vol. 1148, no. 2, pp. 177–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Li, R. Tsao, J. Dou, F. Song, Z. Liu, and S. Liu, “Detection of saponins in extract of Panax notoginseng by liquid chromatography-electrospray ionisation-mass spectrometry,” Analytica Chimica Acta, vol. 536, no. 1-2, pp. 21–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Zhang and Y. Cheng, “Solid-phase extraction and liquid chromatography-electrospray mass spectrometric analysis of saponins in a Chinese patent medicine of formulated Salvia miltiorrhizae and Panax notoginseng,” Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 2, pp. 429–432, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Zhu and Y. J. Tian, “Chemical composition and larvicidal effects of essential oil of Blumea martiniana against Anopheles anthropophagus,” Asian Pacific Journal of Tropical Medicine, vol. 4, no. 5, pp. 371–374, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Rajkumar and A. Jebanesan, “Chemical composition and larvicidal activity of leaf essential oil from Clausena dentata (Willd) M. Roam. (Rutaceae) against the chikungunya vector, Aedes aegypti Linn. (Diptera: Culicidae),” Journal of Asia-Pacific Entomology, vol. 13, no. 2, pp. 107–109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. P. J. Dunlop, C. M. Bignell, J. F. Jackson, and D. B. Hibbert, “Chemometric analysis of gas chromatographic data of oils from Eucalyptus species,” Chemometrics and Intelligent Laboratory Systems, vol. 30, no. 1, pp. 59–67, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. Chinese Pharmacopeia Commission, Pharmacopeia of the People's Republic of China, vol. 1, China Medical Science Publisher, Beijing, China, 2010.
  25. S. S. Yang, K. R. Zhang, X. Lin et al., “Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats,” Journal of Pharmaceutical and Biomedical Analysis, vol. 67-68, pp. 77–85, 2012. View at Google Scholar
  26. Q. F. Xu, X. L. Fang, and D. F. Chen, “Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 187–192, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Li, J. L. Zhang, Y. X. Sheng, G. Ye, H. Z. Guo, and D. A. Guo, “Liquid chromatographic method for determination of four active saponins from Panax notoginseng in rat urine using solid-phase extraction,” Journal of Chromatography B, vol. 808, no. 2, pp. 177–183, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Song, S. Zhang, X. Xu, T. Hang, and L. Jia, “Simultaneous determination of three Panax notoginseng saponins at sub-nanograms by LC-MS/MS in dog plasma for pharmacokinetics of compound Danshen tablets,” Journal of Chromatography B, vol. 878, no. 32, pp. 3331–3337, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Liu, J. Yang, F. Du et al., “Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats,” Drug Metabolism and Disposition, vol. 37, no. 12, pp. 2290–2298, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Yee, “In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man—fact or myth,” Pharmaceutical Research, vol. 14, no. 6, pp. 763–766, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Meng, H. Zhang, Y. Zhao, J. Lan, and L. Du, “Transport behavior and efflux of Rg1 in rat pulmonary epithelial cells,” Biomedical Chromatography, vol. 21, no. 6, pp. 635–641, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Liu, L. Zhang, X. Lan et al., “Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor κappaB signaling pathway,” Neuroscience, vol. 176, pp. 408–419, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. M. Chen and N. S. Wang, “Effect of borneol on the intercellular tight junction and pinocytosis vesicles in vitro blood-brain barrier model,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 24, no. 7, pp. 632–634, 2004. View at Google Scholar · View at Scopus
  34. L. Li, Y. Yuan, and X. H. Jiang, “Absorption mechanism of liposoluble components of Salvia miltiorrhiza with Caco-2 cell model,” Chinese Pharmaceutical Journal, vol. 41, no. 2, pp. 108–112, 2006. View at Google Scholar · View at Scopus
  35. Y. M. Chen and N. S. Wang, “Effect of borneol on P-glycoprotein,” Traditional Chinese Drug Research & Clinical Pharmacology, vol. 14, pp. 96–99, 2003. View at Google Scholar