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Journal of Analytical Methods in Chemistry
Volume 2013 (2013), Article ID 951319, 7 pages
Research Article

Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

1West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China
2West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China

Received 24 January 2013; Accepted 6 March 2013

Academic Editor: Yu-Ming Fan

Copyright © 2013 Ruoshi Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Inhibiting gene β-catenin and inducting genes GSK-3β and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Method. The different genes were scanned by the 4*44K mouse microarray chips. The effect of the three genes was confirmed by RT-PCR technique with CGA dosage of 5, 10, and 20 mg/kg. Result. The expression of GSK-3β and APC was upregulated in group of 20 mg/kg dosage ( ) and the expression of β-catenin was downregulated in the same dosage ( ). Conclusion. The results infer that the multimeric protein complex of β-catenin could be increased by CGA upregulated genes GSK-3β and APC, which could inhibit the free β-catenin into the nucleus to connect with TCF. So the transcriptional expression of the target genes will be cut to abnormal cell proliferation. It is probably one of the ways that can stop the tumor increase by CGA.