Quantification of Photocyanine in Human Serum by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Application in a Pharmacokinetic Study
Figure 2
Representative HPLC-MS/MS chromatograms of extract from (a) blank serum; (b) a human serum sample spiked with mono-β-sulfonated zinc phthalocyanine potassium (IS), (c) a human serum sample spiked with 1000 ng/mL photocyanine and IS, and (d) a patient serum sample after i.v. administration of photocyanine spiked with IS.