Quantification of Photocyanine in Human Serum by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Application in a Pharmacokinetic Study

Table 5

Noncompartmental pharmacokinetic parameters of photocyanine in cancer patients after a single i.v. dose of 0.1 mg/kg photocyanine (n = 6).

Parameters	Mean ± SD
𝑇max (h)^a	1.83 ± 0.41
𝐶max (ng/mL)^b	2465.3 ± 723.0
𝑡1/2 (h)^c	74.62 ± 13.29
AUC0--𝑡^d (ng·mL^−1·h)	53137.2 ± 20210.6
AUC0--∞^e (ng·mL^−1·h)	62634.6 ± 25398.6
𝑉𝑑 (L)^f	11.29 ± 4.12
CL (L/h)^g	0.11 ± 0.04
MRT (h)^h	40.16 ± 4.32

^a𝑇_max: time to maximum concentration; ^b𝐶_max: maximum plasma concentration; ^c𝑡_1/2: half-life of elimination; ^dAUC_0--𝑡: area under the concentration-time curve from time zero to the last quantifiable measurement; ^eAUC_0--∞: area under the concentration-time curve extrapolated to infinity; ^f𝑉_𝑑: volume of distribution; ^gCL: total clearance; ^hMRT: mean residence time.