Research Article
A Comparative Study of Newly Developed HPLC-DAD and UHPLC-UV Assays for the Determination of Posaconazole in Bulk Powder and Suspension Dosage Form
Table 1
Precision and accuracy for the determination of PSZ in bulk form using the proposed HPLC-DAD and UHPLC-UV methods.
| | Nominal PSZ concentration μg/mL | Apparatus used | Intraday mean ± SD (intraday CV%) | Interday, mean ± SD, μg/mL | Interday CV% | Interday mean error% |
| | 5 | HPLC |
(1.56) |
(0.99) |
(1.97) | | 0.99 | 1.43 | | UHPLC |
(0.96) |
(2.78) |
(1.51) | | 1.17 | 0.08 |
| | 20 | HPLC |
(0.64) |
(1.07) |
(1.86) | | 1.56 | −0.14 | | UHPLC |
(1.67) |
(1.74) |
(1.35) | | 2.4 | −1.15 |
| | 50 | HPLC | (0.89) |
(1.36) |
(1.13) | | 1.16 | −0.22 | | UHPLC |
(1.96) |
(1.69) |
(1.33) | | 0.72 | 0.40 |
|
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