Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes

Table 8

Application of the proposed methods for the determination of GMF, MXF, and ENF in their pharmaceutical preparations.

Samples	Reported methods^c	Proposed methods
		BCG	BCP	BPB	BTB	MO
Factive tablets
X ± SD^a	100.08±0.56	99.90±0.62	100.15±0.74	99.75±0.53	99.80±0.71	100.20±0.59
t-value^b		0.20	0.07	0.39	0.28	0.13
F-value^b		1.23	1.75	1.12	1.61	1.11
Flobiotic tablets
X ± SD^a	99.94±0.68	99.68±0.80	99.79±0.57	99.90±0.73	100.10±0.84	100.20±0.77
t-value^b		0.23	0.15	0.04	0.14	0.23
F-value^b		1.38	1.42	1.15	1.53	1.67
GemiQue tablets
X ± SD^a	99.85±0.49	99.70±0.60	100.05±0.57	99.60±0.38	99.96±0.55	99.55±0.63
t-value^b		0.18	0.24	0.37	0.14	0.34
F-value^b		1.50	1.35	1.66	1.26	1.65
Avelox tablets
X ± SD^a	99.03±0.97		99.60±0.74	99.35±0.96	99.10±1.20	99.50±0.82
t-value^b			0.47	0.21	0.04	0.34
F-value^b			1.72	1.02	1.53	1.40
Moxiflox tablets
X ± SD^a	99.34±0.34		99.15±0.52	99.50±0.46	99.62±0.43	99.55±0.60
t-value^b			0.28	0.26	0.47	0.28
F-value^b			2.34	1.83	1.60	3.11
Moxifloxacin tablets
X ± SD^a	99.94±0.92		99.70±1.05	99.85±0.80	100.15±0.98	99.90±0.84
t-value^b			0.16	0.07	0.14	0.03
F-value^b			1.30	1.32	1.13	1.20
Enrocxin 10% injectable
X ± SD^a	99.85±0.43	99.70±0.68			100.10±0.32
t-value^b		0.17			0.43
F-value^b		2.50			1.81
Avitryl 20% injectable
X ± SD^a	99.78±0.64	99.50±0.48			99.46±0.47
t-value^b		0.32			0.37
F-value^b		1.78			1.85

aAverage of six determinations.
bTheoretical values for 𝑡- and 𝐹-values at five degrees of freedom and 95% confidence limit are 𝑡=2.57 and 𝐹=5.05.
cReported spectrophotometric methods for GMF [29], MXF [40], and ENF [44].