Journal of Analytical Methods in Chemistry / 2014 / Article / Tab 3

Research Article

Studies on the Anti-Inflammatory Effect and Its Mechanisms of Sophoridine

Table 3

The influences of SRI on the production of TNF , IL-6, IL-8, and PGE2 in the local inflammatory exudates of carrageenin-induced mouse paw edema model .

GroupDosage (mg/kg) TNF (OD value)
(mean ± SD)
IL-6 (OD value)
(mean ± SD)
PGE2 (OD value)
(mean ± SD)
IL-8 (ng/mL)
(mean ± SD)
Inhibition (%)
TNF IL-6PGE2IL-8

Control0.680 ± 0.0111.341 ± 1.156
Model0.532 ± 0.0233.379 ± 0.2610.303 ± 0.0080.267 ± 0.081
Ibuprofen176.50.437 ± 0.025(2)2.413 ± 0.2100.170 ± 0.029(2)0.146 ± 0.042(2)−64.528.643.745.3
SRI48.600.564 ± 0.0303.167 ± 0.090(2)0.193 ± 0.011(2)0.210 ± 0.044(1)21.66.336.421.3
SRI12.150.547 ± 0.0223.132 ± 0.157(1)0.218 ± 0.040(1)0.256 ± 0.07310.17.327.94.1

Compared with model group, (1) , (2) .