Studies on the Anti-Inflammatory Effect and Its Mechanisms of Sophoridine

Table 3

The influences of SRI on the production of TNF𝛼, IL-6, IL-8, and PGE₂ in the local inflammatory exudates of carrageenin-induced mouse paw edema model (𝑛=12).

Group	Dosage (mg/kg)	TNF (OD value); (mean ± SD)	IL-6 (OD value); (mean ± SD)	PGE2 (OD value); (mean ± SD)	IL-8 (ng/mL); (mean ± SD)	Inhibition (%)
						TNF𝛼	IL-6	PGE2	IL-8
Control		0.680 ± 0.011	1.341 ± 1.156
Model		0.532 ± 0.023	3.379 ± 0.261	0.303 ± 0.008	0.267 ± 0.081
Ibuprofen	176.5	0.437 ± 0.025^(2)	2.413 ± 0.210	0.170 ± 0.029^(2)	0.146 ± 0.042^(2)	−64.5	28.6	43.7	45.3
SRI	48.60	0.564 ± 0.030	3.167 ± 0.090^(2)	0.193 ± 0.011^(2)	0.210 ± 0.044^(1)	21.6	6.3	36.4	21.3
SRI	12.15	0.547 ± 0.022	3.132 ± 0.157^(1)	0.218 ± 0.040^(1)	0.256 ± 0.073	10.1	7.3	27.9	4.1

Compared with model group, ⁽¹⁾𝑃<0.05, ⁽²⁾𝑃<0.01.