Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats

Table 5

Pharmacokinetic parameters of DSS, RA, LA, SAB, and HP in rat plasma after oral administration of a single extract and a combination of both extracts (𝑛=6).

Parameter	DSS	DSS′	RA	RA′	LA	LA′	SAB	SAB′	HP	HP′
AUC0--𝑡 (mg·h/L)	3.65±0.42	4.44±0.66^∗	2.09±0.39	4.25±0.78^∗∗	6.49±0.88	27.3±3.0^∗∗	38.2±3.0	56.5±6.52^∗∗	3.84±0.61	5.24±0.79^∗
AUC0--∞ (mg·h/L)	4.29±0.99	5.22±3.7	3.39±2.3	5.20±1.8	7.05±2.1	27.5±2.8^∗∗	38.7±4.1	59.4±7.64^∗∗	5.99±1.0	6.52±1.2
MRT0--𝑡 (h)	2.98±0.15	2.76±0.10^∗	2.50±0.44	1.98±0.12^∗	3.27±0.50	2.93±0.22	2.85±0.13	3.78±0.19^∗∗	2.68±0.16	2.22±0.20^∗∗
MRT0--∞ (h)	5.52±1.1	5.26±0.75	8.86±5.4	4.24±10.0	5.06±3.9	3.24±0.29^∗	3.38±1.1	4.36±0.36	9.04±1.1	6.80±3.3^∗
𝑇(1/2)𝑧 (h)	2.85±1.2	3.00±8.8	7.52±4.4	4.34±9.0^∗	3.78±3.8	1.60±0.67^∗	1.94±2.1	2.50±0.45	7.00±0.67	5.35±3.0
𝑇max (h)	0.5	0.75	0.5	0.33	0.5	1.0	0.5	1.5	0.75	0.5
𝐶max (mg/L)	1.14±5.8	1.87±0.17^∗∗	1.50±0.44	3.88±0.41^∗∗	3.91±0.41	10.0±0.89^∗∗	13.7±0.88	13.2±1.7	1.93±0.39	3.27±0.48^∗∗

′A combination of both extracts. *𝑃<0.05; **𝑃<0.01; comparison with a single extract (SME or HTE).