Simple and Sensitive Analysis of Blonanserin and Blonanserin C in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry and Its Application

Table 4

Mean pharmacokinetic parameters for blonanserin and blonanserin C (𝑛=6).

Compound	Parameters	4 mg	8 mg	12 mg
Blonanserin	𝑇max (h)	2.37±1.43	1.88±0.75	2.50±1.23
	𝐶max (ng·mL^−1)	0.08±0.02	0.32±0.11	0.49±0.12
	𝑇1/2 (h)	6.42±2.58	15.29±13.06	16.46±3.70
	AUC0--𝑡 (ng·h·mL^−1)	0.56±0.16	2.56±1.10	4.90±1.32
	AUC0--∞ (ng·h·mL^−1)	0.70±0.22	2.88±1.32	5.15±1.33
Blonanserin C	𝑇max (h)	8.50±2.52	9.50±3.00	7.25±3.78
	𝐶max (ng·mL^−1)	0.05±0.02	0.15±0.02	0.24±0.04
	𝑇1/2 (h)	28.52±7.50	26.24±3.93	26.25±2.90
	AUC0--𝑡 (ng·h·mL^−1)	1.50±0.53	5.11±0.33	8.39±1.48
	AUC0--∞ (ng·h·mL^−1)	2.48±0.50	6.10±0.28	10.04±1.49