A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form

Table 1

Summary of forced degradation conditions for STP.

Stress conditions			Exposed conditions	Duration
Thermal stress	Solid/Solution	—	80°C	48 h
Acid/Base degradation	Acid	0.005, 0.01, 0.05, and 0.1 N HCl	60°C	1, 2, and 3 h
	Base	0.05, 0.1, 0.5, and 1 N NaOH	60°C	1, 2, and 3 h
Oxidation	H2O2	1, 6, 10, and 30%	Room temperature	2 h
Photodegradation	Solid/Solution	UV (254 nm)	Room temperature	72 h