Quantitative Analysis of Cepharanthine in Plasma Based on Semiautomatic Microextraction by Packed Sorbent Combined with Liquid Chromatography

Table 2

Pharmacokinetics parameters in healthy and Plasmodium berghei ANKA infected female BALB/c mice after a single intraperitoneal administration of cepharanthine at the dose of 21 mg/kg bodyweight (mean).

Parameters	Healthy mice	Infected mice
𝑇max (h)	0.25	0.25
𝐶max (µg·L^−1)	874	1.088
𝑡1/2elim (h)	2.52	2.59
𝑉𝑑 (L·kg^−1)/F	31.8	30.1
Cl (L·h^−1·kg^−1)/F	8.77	8.04
AUC(0--6h) (µg·h·L^−1)	2069	2205