Research Article
Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems
Table 2
Calcium phosphate solubility in an admixture—conditions for effect of
Ca
2+.
| | Parameter | Setting |
| | Test article | 5% amino acid/15% dextrose with electrolytes | | Container | 1-liter glass bottle | | Temperature (°C) | 37 | | Calcium (mmol/L) | 0.9, 3.9, 5.3, 6.4, 7.3, 8.3, 9.8, and 12.7 | | Phosphates (mmol/L) | 24 | | Threshold particle size (m) | ≥1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 15.0, 25.0, and 50.0 | | Calcium addition | After 2.5 hours, bolus injection to achieve Ca2+ above | | Interval testing | Periodically for approximately 100 hours, approximately every 30 minutes |
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