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Journal of Analytical Methods in Chemistry
Volume 2015, Article ID 294270, 9 pages
http://dx.doi.org/10.1155/2015/294270
Research Article

Quantitative Determination of Lercanidipine Enantiomers in Commercial Formulations by Capillary Electrophoresis

1Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, SP, Brazil
2Departament of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, 14040-901 Ribeirão Preto, SP, Brazil

Received 11 December 2014; Revised 18 February 2015; Accepted 18 February 2015

Academic Editor: Sibel A. Ozkan

Copyright © 2015 Luciana Pereira Lourenço et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Notarbartolo, F. Rengo, V. Scafidi, and D. Acanfora, “Long-term effects of lercanidipine on the lipoprotein and apolipoprotein profile of patients with mild-to-moderate essential hypertension,” Current Therapeutic Research: Clinical and Experimental, vol. 60, no. 4, pp. 228–236, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Fiori, R. Gotti, C. Bertucci, and V. Cavrini, “Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC–UV and LC–ESI–MS/MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 1, pp. 176–181, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Godfraind, “Classification of calcium antagonists,” The American Journal of Cardiology, vol. 59, no. 3, pp. 11B–23B, 1987. View at Google Scholar · View at Scopus
  4. G. A. Goodman, T. W. Rall, A. S. Tweenies, and P. Taylor, The Pharmacological Basis of Therapeutics, McGraw-Hill:, New York, NY, USA, 9th edition, 1992.
  5. N. Buckley, A. Dawson, and I. Whyte, “Calcium channel blockers,” Medicine, vol. 35, no. 11, pp. 599–602, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Testa, A. Leonardi, A. Tajana, E. Riscassi, R. Magliocca, and A. Sartani, “Lercanidipine (Rec 15/2375): a novel 1,4-dihydropyridine calcium antagonist for hypertension,” Cardiovascular Drug Reviews, vol. 15, no. 3, pp. 187–219, 1997. View at Google Scholar · View at Scopus
  7. A. Corsini, M. Bonfatti, P. Quarato et al., “Effect of the new calcium antagonist lercanidipine and its enantiomers on the migration and proliferation of arterial myocytes,” Journal of Cardiovascular Pharmacology, vol. 28, no. 5, pp. 687–694, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Cargnoni, M. Benigno, F. Ferrari et al., “Effects of lercanidipine and its enantiomers on ischemia and reperfusion,” Journal of Cardiovascular Pharmacology, vol. 29, no. 1, pp. S48–S62, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Leonardi, E. Poggesi, C. Taddei et al., “In vitro calcium antagonist activity of lercanidipine and its enantiomers,” Journal of Cardiovascular Pharmacology, vol. 29, no. 1, pp. S10–S18, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Caslavska and W. Thormann, “Stereoselective determination of drugs and metabolites in body fluids, tissues and microsomal preparations by capillary electrophoresis (2000–2010),” Journal of Chromatography A, vol. 1218, no. 4, pp. 588–601, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. P. S. Bonato, V. P. A. Jabor, and C. M. Gaitani, “Análise enantiosseletiva de fármacos: contribuições da cromatografia líquida de alta eficiência e eletroforese capilar,” Química Nova, vol. 28, no. 4, pp. 683–691, 2005. View at Google Scholar
  12. I. I. Salem, J. Idrees, J. I. Al Tamimi, and P. Farina, “Selective and rapid liquid chromatography-mass spectrometry method for the determination of lercanidipine in human plasma,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 803, no. 2, pp. 201–207, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. R. M. De Oliveira, “Análise enantiosseletiva de fármacos e metabólitos empregando a eletroforese capilar,” Scientia Chromatographica, vol. 3, no. 3, pp. 231–247, 2011. View at Publisher · View at Google Scholar
  14. N. Parmar, N. Singla, S. Amin, and K. Kohli, “Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system,” Colloids and Surfaces B: Biointerfaces, vol. 86, no. 2, pp. 327–338, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. E. de Lorenzi, G. Massolini, D. K. Lloyd, H. L. Monaco, C. Galbusera, and G. Caccialanza, “Evaluation of quail egg white riboflavin binding protein as a chiral selector in high-performance liquid chromatography and capillary electrophoresis,” Journal of Chromatography A, vol. 790, no. 1-2, pp. 47–64, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Boatto, M. Nieddu, M. V. Faedda, and P. de Caprariis, “Enantiomeric separation by HPLC of 1,4-dihydropyridines with vancomycin as chiral selector,” Chirality, vol. 15, no. 6, pp. 494–497, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. V. A. P. Jabor, E. B. Coelho, D. R. Ifa, P. S. Bonato, N. A. Guinaim dos Santos, and V. L. Lanchote, “Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography-tandem mass spectrometry,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 796, no. 2, pp. 429–437, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. V. A. P. Jabor, E. B. Coelho, and V. L. Lanchote, “Enantioselective pharmacokinetics of lercanidipine in healthy volunteers,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 813, no. 1-2, pp. 343–346, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. P. S. Bonato, “Recent advances in the determination of enantiomeric drugs and their metabolites in biological fluids by capillary electrophoresis-mediated microanalysis,” Electrophoresis, vol. 24, no. 22-23, pp. 4078–4094, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Fanali, “Chiral separations by CE employing CDs,” Electrophoresis, vol. 30, supplement 1, pp. S203–S210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Tanaka and S. Terabe, “Recent advances in enantiomer separations by affinity capillary electrophoresis using proteins and peptides,” Journal of Biochemical and Biophysical Methods, vol. 48, no. 2, pp. 103–116, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Chankvetadze, Capillary Electrophoresis in Chiral Analysis, John Wiley & Sons, New York, NY, USA, 1997.
  23. A. B. Baranda, R. M. Alonso, R. M. Jiménez, and W. Weinmann, “Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples,” Forensic Science International, vol. 156, no. 1, pp. 23–34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. International Conference on Harmonization (ICH), Validation of Analytical Procedures: Methodology, Technical Requirements for the Registration of Pharmaceuticals for Human Use, International Conference on Harmonization, Geneva, Switzerland, 1996.
  25. M. I. Jimidar, W. van Ael, P. van Nyen, M. Peeters, D. Redlich, and M. De Smet, “A screening strategy for the development of enantiomeric separation methods in capillary electrophoresis,” Electrophoresis, vol. 25, no. 16, pp. 2772–2785, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Weinberger, Practical Capillary Electrophoresis, Academic Press, New York, NY, USA, 2nd edition, 2000.
  27. A. C. Servais, J. Crommen, and M. Fillet, “Factors influencing cyclodextrin mediated chiral spearations,” in Chiral Separations by Capillary Electrophoresis, A. van Eeckhaut and Y. Michotte, Eds., CRC Press, Boca Raton, Fla, USA, 2010. View at Google Scholar
  28. R. Kuhn and S. Hoffstetter-Kuhn, Capillary Electrophoresis: Principle and Practice, Springer Laboratory, Berlin, Germany, 1st edition, 1993.
  29. A. R. Fakhari, S. Nojavan, S. Haghgoo, and A. Mohammadi, “Development of a stability-indicating CE assay for the determination of amlodipine enantiomers in commercial tablets,” Electrophoresis, vol. 29, no. 22, pp. 4583–4592, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Morante-Zarcero, A. L. Crego, I. Sierra, M. Fajardo, and M. L. Marina, “Chiral capillary electrophoresis applied to the determination of phenylglycidol enantiomers obtained from cinnamyl alcohol by asymmetric epoxidation using new titanium(IV) alkoxide compounds as catalysts,” Electrophoresis, vol. 25, no. 16, pp. 2745–2754, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Rizzi, “Fundamental aspects of chiral separations by capillary electrophoresis,” ELECTROPHORESIS, vol. 22, no. 15, pp. 3079–3106, 2001. View at Publisher · View at Google Scholar
  32. C. S. V. Griend, Capillary Electrophoresis Methods for Pharmaceuticals Analysis, edited by A. Ahuja and M. I. Jimidar, Elsevier, London, UK, 2008.
  33. S. Fanali, “Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors,” Journal of Chromatography A, vol. 875, no. 1-2, pp. 89–122, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. F. A. Aguiar, C. M. de Gaitani, and K. B. Borges, “Capillary electrophoresis method for the determination of isradipine enantiomers: stability studies and pharmaceutical formulation analysis,” Electrophoresis, vol. 32, no. 19, pp. 2673–2682, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Heuermann and G. Blaschke, “Chiral separation of basic drugs using cyclodextrins as chiral pseudo-stationary phases in capillary electrophoresis,” Journal of Chromatography A, vol. 648, no. 1, pp. 267–274, 1993. View at Publisher · View at Google Scholar · View at Scopus
  36. The United States Convention, The United States Pharmacopeia, chapter 1225, The United States Convention, Rocjville, Md, USA, 30th edition, 2007.
  37. HMSO, British Pharmacopoeia. International Edition, vol. 1, HMSO, Cambridge, UK, 2004.