Research Article
General Analytical Procedure for Determination of Acidity Parameters of Weak Acids and Bases
Table 10
The p
’s values of compounds with pharmaceutical importance determined in the mixture containing other weak electrolytes 25°C.
| | Composition of D | pKAA ± | pKMes ± | pKPcm ± | pKASA | pKCA |
| | AA + Mes + Pcm | 4.14 ± 0.03 | 6.24 ± 0.04 | 9.95 ± 0.05 | — | — |
| | Composition of D | pKASA ± | pKImH ± | pKEph ± | — | — |
| | ASA + ImH + Eph * HCl | 3.49 ± 0.03 | 7.21 ± 0.06 | 9.94 ± 0.05 | — | — |
| | Composition of D | pKMet ± | pKImH ± | pKMes ± | — | — |
| | Met + ImH + Mes | 2.28 ± 0.04 | 7.35 ± 0.02 |
6.19 ± 0.01 | — | — |
| | Composition of D | pKASA ± | pKMes ± | p ± s | — | — |
| | ASA + Mes + L-His | 3.57 ± 0.03 | 6.29 ± 0.03 | p = 1.54*
p = 5.96 ± 0.05
p = 9.67 ± 0.59 | — | — |
| | Composition of D | pKKTL ± | pKMes ± | p ± s | — | — |
| | KTL + Mes + L-His | pK1 3.09 ± 0.05
pK2 6.15* | 6.15* | p = 6.15*
p = 9.58 ± 0.06 | — | — |
| | Composition of D | pKAA ± | pKMes ± | pKPpv ± s | pKASA | pKCA |
| | AA + Mes + Ppv | 4.24 ± 0.02 | 6.55 ± 0.03 | 6.02 ± 0.06 | — | — | | AA + Mes + ASA + CA | 4.05 ± 0.16 | — | — | 3.90 ± 0.16 | pK1 = 2.53 ± 0.30
pK2 = 5.03 ± 0.33
pK3 = 6.5 ± 0.34 |
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*p value const. from the literature [see Table 11].
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